About: Molecular characterization of autoimmune polyglandular syndromes     Goto   Sponge   NotDistinct   Permalink

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Description
  • It is the goal of the submitted project to investigate a possible link of genetic predisposition and immunological features in autoimmune polyglandular syndromes (APS). One important question is whether or not clinically silent and overt forms of APS canbe differentiated by their genetic predisposition. The immunological studies will focus on both B- and T-cell mediated autoimmune responses. A broad range of recombinant antigens that were generated at IPM, Hamburg, can be used for a sensitive and specific diagnosis of APS. Because the T-cell mediated autoimmune response is crucial for the pathogenesis of APS the recombinant proteins also can be used for detection of autoreactive T-cells and the Th1/Th2-balance can be determined by ultrasensitive RT-PCR. Eventually, the specific detection of autoreactive T cells might have a great impact on future treatment of the autoimmune disease already in the subclinical state. (en)
  • Cílem předloženého projektu je zjistit možnou vazbu mezi genedickou predizpozicí a rozvojem imunopatologických znaků u autoimunitního polyglandulárního syndromu (APS). Jednou z hlavních otázek je zda klinicky rozvinutý a nerozvinutý APS může mít odlišnosti v genetické predizpozici. Imunologické studie se zaměří na význam B a T lymfocytů v autoimunitním procesu.
Title
  • Molecular characterization of autoimmune polyglandular syndromes (en)
  • Molekulární charakteristika autoimunitního poplyglandulálního syndromu
skos:notation
  • ME 375
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  • autoimmune polyglandular syndrom; genetic predisposition; Th1/Th2-balance (en)
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  • Exprese HLA antigenů ukazuje na genetickou rozdílnost mezi izolovanou autoimunitní tyreoiditidou a oběma skupinami s polyglandulárními projevy. (cs)
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  • genetic predisposition
  • autoimmune polyglandular syndrom
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