About: Identification of protein complexes associated with genotoxic RNA:DNA hybrids and their role in maintenance of genomic stability     Goto   Sponge   NotDistinct   Permalink

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Description
  • Cílem tohoto projektu je vyvinout metodu pro izolaci proteinových komplexů asociovaných s RNA:DNA hybridy, identifikovat proteiny přítomné v těchto komplexech za podmínek vedoucích k interferenci mezi replikací a transkripcí a ověřit zda jsou potřebné k udržení genomové stability.
  • The aim of this project is to prepare tools for the isolation of proteins associated with R-loops, identify proteins associated with these structures under different conditions promoting transcription/replication collision and R-loop formation and validate their role in maintenance of genomic stability. (en)
Title
  • Identification of protein complexes associated with genotoxic RNA:DNA hybrids and their role in maintenance of genomic stability (en)
  • Identifikace proteinů asociovaných s genotoxickými RNA:DNA hybridy a studium jejich úlohy v udržení genomové stability
skos:notation
  • LH14037
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  • R-loops; RNA:DNA hybrid; transcription/replication collision; replication stress; genomic instability (en)
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  • replication stress
  • RNA:DNA hybrid
  • transcription/replication collision
  • R-loops
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