About: The role of Ganoderma Lucidum in the regulation of NFkappaB-dependent DNA repair-proteasome interactions in colorectal carcinogenesis     Goto   Sponge   NotDistinct   Permalink

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Description
  • To investigate if and how Ganoderma extracts influence DNA repair on phenotypic and genetic levels along with signal transduction pathways in colorectal cancer cell lines. To uncover the basic mechanisms of response of tumor cells to the genotoxic stress with and without GL intervention with particular emphasize to the characterization of DNA repair capacity. Experimentally-induced DNA damage in both normal and malignant cell lines in line with addressing of the genotoxic stress-response mechanisms (e.g. is the repair capacity increased in tumor cells?) contribute to the understanding of the behavior of these cells in order to implement an optimal intervention. Finally, based on our experimental results and revealed mechanisms of GL- anti-cancer action we would define conditions and recommendations under which the GL-might be implemented and beneficial to the cancer patient in the individualized anticancer therapy. (en)
  • Charakterizovat a kvantifikovat DNA reparační kapacitu, zejména u drah, které se účastní excizních oprav. - Charakterizovt signální dráhy NFkB a dráhy DNA oprav v nádorových buňkách tlustého střeva a vhodných kontrolních buněčných liniích po expozicí extraktu Ganodermy Lucidum - Zkoumat signální dráhy a dráhy DNA oprav v nádorových buňkách tlustého střeva a vhodných kontrolních buněčných liniích po specifickém poškození DNA vyvolaném H2O2, propylenoxidem a benzo(a)pyren diolepoxidem a expozicí extraktu GL - Studovat regulaci NfkappaB prostřednictvím miRNA a reakce na změny buněčného prostředí zprostředkovaná NRF1
Title
  • The role of Ganoderma Lucidum in the regulation of NFkappaB-dependent DNA repair-proteasome interactions in colorectal carcinogenesis (en)
  • Vliv extraktu Ganoderma Lucidum na regulaci interakcí mezi NF-kB, DNA opravami a proteosomy v kolorektální karcinogeneze
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  • cell lines - colorectal cancer - DNA repair - anticancer effect - Ganoderma Lucidum (en)
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