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Description
  • Identifikace klíčových vlastností vybraných průmyslových důležitých nanočástic z hlediska jejich možné cytotoxicity a konstrukce validovaných QNTR modelů predikujících cytotoxicitu těchto nanočástic.
  • Major aim of this project is gaining od the relevant models to predict the cytotoxicity of selected well characterized nanomaterials (NM) ussing matematical modelling and standardized protocols for cytotoxicity measurement in human lung cell lines A549 and BEAS-2B. The project will contribute to identification od the most important physico-chemical features decisive for their cytoxicity by metodology of the quantitative structure-activity relationship (QSAR). These mathematical models will be instruments to predict cytotoxicity with the aim to limit the extent of the experiments on laboratory animals. The project will be solved in close cooperation with European partners participating i the COST Action TD 1204 MODENA providing us with well characterized NMs. The MODENA partners will also construct and validate the QNTR models (QSAR for NMs). The final goals of the project are valid models predicting cytotoxicity of selected NMs applicable in their development safe by design. (en)
Title
  • Toxic effects of nanomaterials as a function of their structure and physicochemical properties (en)
  • Toxické účinky nanomateriálů jako funkce jejich struktury a fyzikálně-chemických vlastností
skos:notation
  • LD14002
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  • nanomaterials; nanotoxicology; cytotoxicity; QNTR (en)
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  • nanomaterials
  • cytotoxicity
  • nanotoxicology
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