About: Membrane signalosomes of mast cells and basophils

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Projekt, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/domain/vavai/Projekt
rdfs:seeAlso	http://www.isvav.cz/projectDetail.do?rowId=LD12073
Description	The aim of this project is: 1. To contribute to determining the composition of the FceRI membrane signalosomes important for antigen-induced degranulation in mast cells. 2. To contribute to determining the composition of membrane signalosomes important for antigen-induced adhesion and chemotaxis in mast cells. 3. To determine new modulators (inhibitors/activators) of antigen-induced degranulation, adhesion and chemotaxis in mouse and human mast cells. (en) Cílem projektu je 1. Přispět k určení složení FceRI membránových signalosomů důležitých pro degranulaci žírných buněk. 2. Přispět k určení složení membránových signalosomů důležitých pro antigenem indukovanou adhezi a chemotaxi u žírných buněk 3. Určit nové modulátory (inhibitory/aktivátory) antigenem indukované adheze, chemotaxe a degranulace u myších a lidských žírných buněk.
Title	Membrane signalosomes of mast cells and basophils - targets for innovative therapies (en) Membránové signalosomy žírných buněk a bazofilů - cíle pro inovativní terapie
skos:notation	LD12073
http://linked.open...avai/cep/aktivita	COST CZ
http://linked.open...kovaStatniPodpora	http://linked.opendata.cz/resource/domain/vavai/projekt/LD12073/celkovaStatniPodpora
http://linked.open...ep/celkoveNaklady	http://linked.opendata.cz/resource/domain/vavai/projekt/LD12073/celkoveNaklady
http://linked.open...datumDodatniDoRIV	2015-01-05 (xsd:date)
http://linked.open...i/cep/druhSouteze	VS - Veřejná soutěž ve výzkumu a vývoji
http://linked.open...ep/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open.../cep/fazeProjektu	100427921
http://linked.open...ai/cep/hlavniObor	EC - Imunologie
http://linked.open...vai/cep/kategorie	ZV - Základní výzkum
http://linked.open.../cep/klicovaSlova	mast cell; IgE receptor; immunoreceptor-induced activation; shRNA; lentiviral transduction (en)
http://linked.open...ep/partnetrHlavni	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...inujicichPrijemcu	0 (xsd:int)
http://linked.open...cep/pocetPrijemcu	1 (xsd:int)
http://linked.open...ocetSpoluPrijemcu	0 (xsd:int)
http://linked.open.../pocetVysledkuRIV	9 (xsd:int)
http://linked.open...enychVysledkuVRIV	9 (xsd:int)
http://linked.open...lneniVMinulemRoce	2013-02-25 (xsd:date)
http://linked.open.../prideleniPodpory	http://linked.opendata.cz/resource/domain/vavai/cep/prideleniPodpory/MSMT-2%2F2013-311
http://linked.open...iciPoslednihoRoku	2014
http://linked.open...atUdajeProjZameru	2014
http://linked.open.../vavai/cep/soutez	SMSM2012LD2
http://linked.open...usZobrazovaneFaze	DRRVK
http://linked.open...ai/cep/typPojektu	P - Projekt výzkumu a vývoje financovaný ze státního rozpočtu
http://linked.open...ep/ukonceniReseni	2014-12-31 (xsd:date)
http://linked.open.../cep/vedlejsiObor	EB - Genetika a molekulární biologie ED - Fyziologie
http://linked.open...ep/zahajeniReseni	2012-03-01 (xsd:date)
http://linked.open...tniCyklusProjektu	ZBK
http://linked.open.../cep/klicoveSlovo	mast cell IgE receptor immunoreceptor-induced activation shRNA
is http://linked.open...vavai/riv/projekt of	Multiple Regulatory Roles of the Mouse Transmembrane Adaptor Protein NTAL in Gene Transcription and Mast Cell Physiology Molecular targets on mast cells and basophils for novel therapies Cross-talk between Tetraspanin CD9 and Transmembrane Adaptor Protein Non-T Cell Activation Linker (NTAL) in Mast Cell Activation and Chemotaxis Quantification of alpha-tubulin isotypes by sandwich ELISA with signal amplification through biotinyl-tyramide or immuno-PCR Transmembrane Adaptor Protein PAG/CBP Is Involved in both Positive and Negative Regulation of Mast Cell Signaling Fc receptor-γ subunits with both polar or non-polar amino acids at position of T22 are capable of restoring surface expression of the high-affinity IgE receptor and degranulation in γ subunit-deficient rat basophilic leukemia cells COST BM1007 Meeting in Prague Mast cell chemotaxis - chemoattractants and signaling pathways Membrane-Cytoskeleton Dynamics in the Course of Mast Cell Activation
is http://linked.open...vavai/cep/projekt of	http://linked.opendata.cz/resource/domain/vavai/cep/ucast/LD12073/2012/ico%3A68378050 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/LD12073/2013/ico%3A68378050 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/LD12073/2014/ico%3A68378050

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