About: Structural studies of protein-RNA complexes involved in RNA quality control

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Projekt, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/domain/vavai/Projekt
rdfs:seeAlso	http://www.isvav.cz/projectDetail.do?rowId=LA08008
Description	Cells seem to leave nothing to chance, including the quality control at all steps of information transfer. RNA maturation involves extensive processing that has a relatively high error rate. Cells have developed an RNA quality control mechanism which identifies improperly processed RNAs and subsequently degrades them. This mechanism ensures that only properly processed RNAs are engaged in protein synthesis. The exosome and Trf4 complex are the central molecular machines in this process. The Trf4 complex recognizes and polyadenylates the aberrant RNAs, whereas the exosome is responsible for their degradation. We propose here to use multidimensional NMR spectroscopy to determine the three-dimensional structure of several protein-RNA complexes that are involved in RNA quality control. The proposed project will reveal the mechanism by which the Trf4 complex identifies the aberrant RNAs and thus recruit them for the degradation machinery. (en) Budou získány strukturní informace o tom jak proteiny účastnící se kontroly kvality RNA rozpoznávají poškozenou či mutovanou RNA.
Title	Structural studies of protein-RNA complexes involved in RNA quality control (en) Strukturní studium interakcí mezi bíkovinami a poškozenou RNA.
skos:notation	LA08008
http://linked.open...avai/cep/aktivita	INGO
http://linked.open...kovaStatniPodpora	http://linked.opendata.cz/resource/domain/vavai/projekt/LA08008/celkovaStatniPodpora
http://linked.open...ep/celkoveNaklady	http://linked.opendata.cz/resource/domain/vavai/projekt/LA08008/celkoveNaklady
http://linked.open...datumDodatniDoRIV	2011-06-30 (xsd:date)
http://linked.open...i/cep/druhSouteze	VS - Veřejná soutěž ve výzkumu a vývoji
http://linked.open...ep/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open.../cep/fazeProjektu	82543745
http://linked.open...ai/cep/hlavniObor	CE - Biochemie
http://linked.open...hodnoceniProjektu	V - Vynikající výsledky (s mezinárodním významem apod.). Zároveň byly splněny cíle a předpokládané výsledky uvedené ve smlouvě / rozhodnutí o poskytnutí podpory.
http://linked.open...vai/cep/kategorie	ZV - Základní výzkum
http://linked.open.../cep/klicovaSlova	RNA quality control; misfolded RNA; RNA turnover; RNA recognition; protein-RNA complexes; structure; nuclear magnetic resonance (en)
http://linked.open...ep/partnetrHlavni	Přírodovědecká fakulta
http://linked.open...inujicichPrijemcu	0 (xsd:int)
http://linked.open...cep/pocetPrijemcu	1 (xsd:int)
http://linked.open...ocetSpoluPrijemcu	0 (xsd:int)
http://linked.open.../pocetVysledkuRIV	8 (xsd:int)
http://linked.open...enychVysledkuVRIV	8 (xsd:int)
http://linked.open...lneniVMinulemRoce	2010-12-03 (xsd:date)
http://linked.open.../prideleniPodpory	http://linked.opendata.cz/resource/domain/vavai/cep/prideleniPodpory/1208%2F2010-32
http://linked.open...iciPoslednihoRoku	2010
http://linked.open...atUdajeProjZameru	2011
http://linked.open.../vavai/cep/soutez	SMSM2008LA3
http://linked.open...usZobrazovaneFaze	DUU
http://linked.open...ai/cep/typPojektu	P - Projekt výzkumu a vývoje financovaný ze státního rozpočtu
http://linked.open...ep/ukonceniReseni	2010-12-31 (xsd:date)
http://linked.open.../cep/vedlejsiObor	EB - Genetika a molekulární biologie
http://linked.open...ep/zahajeniReseni	2008-01-01 (xsd:date)
http://linked.open...jektu+dodavatelem	Tento projekt se zabýval studiem mechnismu interakcí mezi proteiny a RNA na strukturní úrovni. Zjistili jsme jak proteiny, které se účastní transkční terminace a editace RNA, rozpoznávají své substráty.Výsledky tohoto projektu byly publikovány ve formě 4 článků v mezinárodních recenzovaných časopisech (Cell, Journal of Biological Chemistry, Biomolecular NMR Assignments). (cs) In this project, we used structural biology approach to study protein-RNA interactions. We solved two protein-RNA structures involved in transcription termination and RNA editing. These structures provided structural basis for how their RNA substrates are recognized. The results from this project were published in peer-reviewed journals (Cell, Journal of Biological Chemistry, Biomol NMR Assign). (en)
http://linked.open...tniCyklusProjektu	ZBKU
http://linked.open.../cep/klicoveSlovo	RNA recognition structure RNA turnover misfolded RNA protein-RNA complexes RNA quality control
is http://linked.open...vavai/riv/projekt of	(1)H, (13)C, and (15)N chemical shift assignments for the RNA recognition motif of Nab3. 1H, 13C, and 15N chemical shift assignments of ZCCHC9 The Solution Structure of the ADAR2 dsRBM-RNA Complex Reveals a Sequence-Specific Readout of the Minor Groove 1H, 13C, and 15N resonance assignments for the CTD-Interacting Domain of Nrd1 bound to Ser5-phosphorylated CTD of RNA Polymerase II Structure and RNA binding of Nab3 Recognition of transcription termination signal by the nuclear polyadenylated RNA-binding (Nab)3 protein Transcription termination of nonpolyadenylated transcripts Recognition of phosphorylated CTD of RNA Pol II by Nrd1
is http://linked.open...vavai/cep/projekt of	http://linked.opendata.cz/resource/domain/vavai/cep/ucast/LA08008/2008/orjk%3A14310 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/LA08008/2009/orjk%3A14310 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/LA08008/2010/orjk%3A14310 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/LA08008/2011/orjk%3A14310

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