About: The idtroduction of comparative genomic hybridization in chidhood ALL to detection and study of clinical importance of genetic changes.     Goto   Sponge   NotDistinct   Permalink

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  • The introducing of the method of CGH,used in the detect. of chromosom. aberrations in childhood ALL.The differentially labeled tumor and control DNA are cohybridized to normal chromosomes under suppress. conditions and detected using defferent fluorochr.The ratios of fliorescence intensities generated by tumor and normal DNA indicated regions with a normal genomic content as well as overrepresented and underrepresented sequences within the tumor DNA. (en)
  • ZavedenÝ metody CGH a jejÝ u×itÝ v detekci chromosomovřch zmýn u dýtskřch ALL.RozdÝlný znaŔenß kontrolnÝ a nßdorovß DNA jsou souŔasný hybridizovßny k normßlnÝm chromosom¨m za supresnÝch podmÝnek a detekovßny rozdÝlnřmi fluorochromy. Pomýry fluorescenŔnÝch intenzit tvo°enÚ nßdorovou a kontrolnÝ DNA urŔujÝ oblasti v nßdorovÚ DNA s normßlnÝmi sekvencemi stejný jako s chybýnÝm Ŕi nadbytkem.Nßdorovß DNA bude izolovßna z hemopoetickřch bunýk dýtÝ s ALL.
Title
  • The idtroduction of comparative genomic hybridization in chidhood ALL to detection and study of clinical importance of genetic changes. (en)
  • Zavedení komparativní genomické hybridizace (CGH) pro zpřesnění detekce a studium klinické významnosti genetických změn u dětských ALL.
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  • IZ4026
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