About: Tissue engineering of the skin and central nervous system

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Projekt, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/domain/vavai/Projekt
rdfs:seeAlso	http://www.isvav.cz/projectDetail.do?rowId=IBS4050005
Description	The development of tissue engineered device for the grafting of human epidermal cells to the bed of skin defect improving the healing is the main aim of the project. The of bioactive implants improvint the healing of central nervous system (CNS) defects (brain tumors and spinal cord defects) and system for the treatment of neurodegenerative diseases by the neuron grafting will be also prepared. The divices for the grafting of human epidermal cells are under clinical trial and in course of project they will be improved for the extensive clinical use. The device for the CNS treatment will be developed to the stage of the animal testing in miniature pigs. The same model will be employed for the testing of the use of embryonic stem cells in the tissue engineering of skin and CNS. (en) Cílem projektu je vývoj tkáňově inženýrské pomůcky pro transplantaci lidských epidermálních buněk do oblasti kožního defektu a tak urychlit hojení. Dále budou připravovány bioaktivní implantáty urychlující hojení centrální nervového systému (CNS, defekt po mozkovém tumoru, mížní léze) a systémy pro transplantaci neuronů pacientům s neurodegenerativními poruchami. Zatímco základní systém pro transplantaci epidermálních buněk je již klinicky testován a v průběhu projektu bude zdokonalen pro široké klinické užití, pomůcky pro terapii CNS budou vyvíjeny do stádia preklinického testování na modelu miniaturního prasete. Na témže modelu bude rovněž ověřováno potencionální užití embryonálních kmenových buněk ve tkáňovém inženýrství kůže a CNS.
Title	Tissue engineering of the skin and central nervous system (en) Tkáňové inženýrství kůže a centrálního nervového systému
skos:notation	IBS4050005
http://linked.open...avai/cep/aktivita	Scheme of targeted research and development support
http://linked.open...kovaStatniPodpora	http://linked.opendata.cz/resource/domain/vavai/projekt/IBS4050005/celkovaStatniPodpora
http://linked.open...ep/celkoveNaklady	http://linked.opendata.cz/resource/domain/vavai/projekt/IBS4050005/celkoveNaklady
http://linked.open...datumDodatniDoRIV	2005-06-17 (xsd:date)
http://linked.open...i/cep/druhSouteze	VS - Veřejná soutěž ve výzkumu a vývoji
http://linked.open...ep/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open.../cep/fazeProjektu	1753804
http://linked.open...ai/cep/hlavniObor	CD - Makromolekulární chemie
http://linked.open...hodnoceniProjektu	V - Vynikající výsledky (s mezinárodním významem apod.). Zároveň byly splněny cíle a předpokládané výsledky uvedené ve smlouvě / rozhodnutí o poskytnutí podpory.
http://linked.open...vai/cep/kategorie	NV - Aplikovaný výzkum s výjimkou průmyslového výzkumu (tzv. %22neprůmyslový výzkum%22)
http://linked.open.../cep/klicovaSlova	tissue engineering;cell therapy;cell transplantation;skin defects;wound healing;central nervous system;neurodegenerative diseases;embryonic stem cells (en)
http://linked.open...ep/partnetrHlavni	Ústav makromolekulární chemie AV ČR, v. v. i.
http://linked.open...inujicichPrijemcu	0 (xsd:int)
http://linked.open...cep/pocetPrijemcu	1 (xsd:int)
http://linked.open...ocetSpoluPrijemcu	3 (xsd:int)
http://linked.open.../pocetVysledkuRIV	25 (xsd:int)
http://linked.open...enychVysledkuVRIV	25 (xsd:int)
http://linked.open...okUkonceniPodpory	2004
http://linked.open...okZahajeniPodpory	2000
http://linked.open...iciPoslednihoRoku	2005
http://linked.open...atUdajeProjZameru	2005
http://linked.open.../vavai/cep/soutez	SAV0-SS2000
http://linked.open...usZobrazovaneFaze	DUU
http://linked.open...ai/cep/typPojektu	P - Projekt výzkumu a vývoje financovaný ze státního rozpočtu
http://linked.open.../cep/vedlejsiObor	EA - Morfologické obory a cytologie FJ - Chirurgie včetně transplantologie
http://linked.open...jektu+dodavatelem	The new polymer support enabling transplantation of keratinocytes after their cultivation without any feeder cells was prepared for skin defects treatment. As implants into CNS we developed hydrogels with controlled degradation period of range 2-42 days. (en) Pro léčbu kožních defektů byl připraven nový typ polymerního nosiče, který umožňuje transplantaci keratinocytů po jejich přímé kultivaci bez podpůrných buněk. Pro implantaci do CNS jsme vyvinuli škálu hydrogelů s nastavitelnou dobou štěpení 2-42 dnů. (cs)
http://linked.open...tniCyklusProjektu	ZBBBKU
http://linked.open.../cep/klicoveSlovo	tissue engineering cell therapy central nervous system wound healing neurodegenerative diseases cell transplantation skin defects
is http://linked.open...vavai/riv/projekt of	Detection of cell type and marker specificity of nuclear binding sites for anionic carbohydrate ligands Macroporous hydrogels based on 2-hydroxyethyl methacrylate. Part 4: Growth of rat bone marrow stromal cells in three-dimensional hydrogels with positive and negative surface charges and in polyelectrolyte complexes Macroporous hydrogels based on 2-hydroxyethyl methacrylate. Part 5: Hydrolytically degradable materials. Macroporous hydrogels based on 2-hydroxyethyl methacrylate. Part 3. Hydrogels as carriers for immobilization of proteins Macroporous hydrogels based on 2-hydroxyethyl methacrylate. Part 2. Copolymers with positive and negative charges, polyelectrolyte complexes Expression of galectin-3-reactive glycoligands in squamous cell cancer Galectin receptors of normal and dystrophic corneas Glycobiological characterization of human epidermis - a view on cell differentiation Expression of galectins and their glycoligands in squamous cell epithelia-clinical consequences Grafting of human epidermal cells, presence and perspectives. Functional consequences of the glycophenotype of squamous epithelia - Practical employment Macroporous hydrogels based on 2-hydroxyethyl methacrylate. Part III. Hydrogels as carriers for immobilization of proteins Macroporous hydrogels based on 2-hydroxyethyl methacrylate. Part II. Copolymers with positive and negative charges, polyelectrolyte complexes Macroporous hydrogels based on 2-hydroxyethyl methacrylate Comparative phenotypic characterization of keratinocytes originating from hair follicles Cell therapy and wound healing - state of art and perspectives. Cell therapy in relationship to contemporary therapeutic technologies - for and against Macroporous hydrogels based on 2-hydroxyethyl methacrylate. Part 1. Copolymers of 2-hydroxyethyl methacrylate with methacrylic acid Dendritic cells and their role in skin-induced immune response Selective binding of Galectin-1 to cell nuclei of epidermal cells Reconstruction of epidermis by grafting of keratinocytes cultured on polymer support - clinical study Glycophenotype of squamous epithelia: from laboratory to clinical practice Glycophenotype of squamous epithelia: from laboratory to clinical practice Topographical properties of polymer films deposited in capillaries for electrophoretic separations of large organic molecules Timing of Plk1 and MPF activation during porcine oocyte maturation
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