About: Chronic intestinal inflammation in animal models and in man: role of microflora, food components and immune factors

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About: Chronic intestinal inflammation in animal models and in man: role of microflora, food components and immune factors Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Projekt, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/domain/vavai/Projekt
rdfs:seeAlso	http://www.isvav.cz/projectDetail.do?rowId=IAA7020716
Description	The aim of our project is to investigate the role of microflora and food components in chronic intestinal inflammation. Immunodeficient animal models with spontaneously or experimentally induced intestinal inflammation will be used. In order to find environmental antigen responsible for inflammation, mice with IL-2 disrupted gene will be reared in germfree conditions and colonised with various bacterial strains. We will concentrate our attention to immune factors which may influence the development of intestinal lesions. Specifically the role of leukocyte recirculation in fucosyltransferase knockout and control mice will be determined. Moreover, we plan to elucidate the role of impairment of oral tolerance to luminal antigens in triggering of autoimmune reactions. For comparison, biopsy material and sera from patients with inflammatory bowel disease and celiac disease will be analysed. (en) Podstatou navrhovaného projektu je zjistit, jakou úlohu při vývoji nespecifických střevních zánětů hrají antigeny mikroflory a potravy a které subpopulace střevních buněk jsou odpovědné za poškození střevní sliznice. Pro analysu imunitních mechanismů využijeme zvířecí modely s poruchami imunoregulace (myši s cílenou delecí IL-2 a fucosyltransferas), u kterých byl popsán spontánní nebo indukovaný vznik chronických střevních zánětů (pokud byly chovány v konvenčním prostředí). Tyto myši budou chovány nebo převedeny do bezmikrobního prostředí a bude provedena kolonizace jejich střev definovanou mikroflorou. Analysa imunitních reakcí nastávajících pro zatížení příslušnými mikroorganismy nebo antigeny bude použita ke srovnání s imunologickými nálezy u pacientů.
Title	Chronic intestinal inflammation in animal models and in man: role of microflora, food components and immune factors (en) Chronické střevní záněty v experimentálních modelech a u lidí: úloha antigenů mikroflory, potravy a imunitních faktorů při vzniku onemocnění
skos:notation	IAA7020716
http://linked.open...avai/cep/aktivita	Grants of distinctly investigative character focused on the sphere of research pursued at present particularly in the Academy of Sciences of the Czech Republic
http://linked.open...kovaStatniPodpora	http://linked.opendata.cz/resource/domain/vavai/projekt/IAA7020716/celkovaStatniPodpora
http://linked.open...ep/celkoveNaklady	http://linked.opendata.cz/resource/domain/vavai/projekt/IAA7020716/celkoveNaklady
http://linked.open...ep/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open.../cep/fazeProjektu	596890
http://linked.open...ai/cep/hlavniObor	FN - Epidemiologie, infekční nemoci a klinická imunologie
http://linked.open...hodnoceniProjektu	V - Vynikající výsledky (s mezinárodním významem apod.). Zároveň byly splněny cíle a předpokládané výsledky uvedené ve smlouvě / rozhodnutí o poskytnutí podpory.
http://linked.open...ep/partnetrHlavni	Mikrobiologický ústav AV ČR, v.v.i.
http://linked.open...inujicichPrijemcu	0 (xsd:int)
http://linked.open...cep/pocetPrijemcu	1 (xsd:int)
http://linked.open...ocetSpoluPrijemcu	0 (xsd:int)
http://linked.open.../pocetVysledkuRIV	36 (xsd:int)
http://linked.open...enychVysledkuVRIV	36 (xsd:int)
http://linked.open...iciPoslednihoRoku	2001
http://linked.open...atUdajeProjZameru	2001
http://linked.open...usZobrazovaneFaze	DUU
http://linked.open...ai/cep/typPojektu	P - Projekt výzkumu a vývoje financovaný ze státního rozpočtu
http://linked.open.../cep/vedlejsiObor	EC - Imunologie EE - Mikrobiologie, virologie
http://linked.open...jektu+dodavatelem	V patogeneze střevních zánětů hrají rozhodující úlohu faktory regulující vstup buněk do místa zánětu (molekula ICAM-1), luminální obsah (složení mikroflory) a struktura potravinových antigenů. (cs)
http://linked.open...tniCyklusProjektu	ZBBKU
is http://linked.open...vavai/riv/projekt of	Lipopolysaccharide receptor CD14 is expressed on beta cells: a molecular basis for innate anti-beta cell immunity IgA autoantibodies to enterocyte antigens and human calreticulin in coeliac disease. Phenotypical characterization of intestinal lymphocytes from rats with gluten enteropathy. Differences in enterocyte brush border enzyme activities in ageing rats reared in germ-free and conventional conditions. Probiotics and E.coli infections in man. The effect of microbial colonization on the intestinal lymphocyte subsets in rats. Effector mechanisms in intestinal immunity and inflammation. Malignancy in coeliac disease and dermatitis herpetiformis. Vliv perorálního osídlení nepatogenním kmenem E.coli po narození na složení střevní flóry, imunitní odpověď a výskyt nozokomiálních infekcí u donošených a nedonošených dětí. Increased levels of circulating ICAM-1, E-selectin, and IL-2 receptors in celiac disease. Malignancy in coeliac disease and dermatitis herpetiformis. Response to gliadin feeding in ummunodeficient mouse model. Autoimmunity, immunodeficiency and mucosal infections: chronic intestinal inflammation as a sensitive indicator of immunoregulatory defects in response to normal luminal microflora. Brush border enzyme activities in the small intestine after long-term gliadin feeding in animal models of human coeliac disease. Overview of the second international workshop to define swine cluster of differentiation (CD) antigens. Identification of common epitopes on gliadin, enterocytes, and calreticulin recognised by antigliadin antibodies of patients with coeliac disease. In vitro immunoglobulin response of fetal B-cells is influenced by perinatal infections and antibiotic treatment: a study in preterm infants. Immunopathogenetic mechanisms of coeliac disease. Gluten-free diet prevents diabetes in NOD mice. The role of mucosal microbiota in the development and maintenance of the mucosal immune system. Role of immunosuppressive therapy in refractory sprue-like disease. Activation of macrophages by food antigens:enhancing effect of gluten on nitric oxide and cytokine production. Detection of ICAM-1 in experimentally induced colitis of ICAM-1-deficient and wild-type mice: an immunohistochemical study. Intercellular adhesion molecule-1 (ICAM-1) deficiency protects mice against severe forms of experimentally induced colitis. Oral administration of antigens from intestinal flora anaerobic bacteria reduces the severity of experimental acute colitis in BALB/c mice. CD14 is expressed adn released as soluble CD14 by human intestinal epithelial cells in vitro: Lipopolysaccharide activation of epithelial cells revisited B-1 lymphocytes: development, functions in the systemic and mucosal imunity, the involvement in autoimmunity CD14 is expressed and released as soluble CD14 by human intestinal epithelial cells in vitro: lipopolysaccharide activation of epithelial cells revisited. The elispot assay for the detection and enumeration of immunoglobulin-, antibody- and/or cytokine. Gnotobiology as a tool - An introduction. Enzymatic activities of enterocytes in experimental models of coeliac disease. Morphological and immunological changes of jejunal mucosa after application of gliadin in rats and protective effect of mothers milk. Ontogeny of CD2 expression on porcine B cells. Autoimmune reactions induced by gliadin feeding in germ-free AVN rats and athymic nude mice. Anti-gliadin antibodies in patients with celiac disease cross-react with enterocytes and human calreticulin. The interaction of epithelial cells with bacterial components: CD14 expression on human epithelial cell lines
is http://linked.open...vavai/cep/projekt of	http://linked.opendata.cz/resource/domain/vavai/cep/ucast/IAA7020716/1997/ico%3A61388971 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/IAA7020716/1997/ico%3A68378050 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/IAA7020716/1998/ico%3A61388971 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/IAA7020716/1998/ico%3A68378050 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/IAA7020716/1999/ico%3A61388971 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/IAA7020716/1999/ico%3A68378050 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/IAA7020716/2000/ico%3A61388971 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/IAA7020716/2000/ico%3A68378050 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/IAA7020716/2001/ico%3A61388971

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