About: Mechanism of hypoxic pulmonary hypertension in newborns and adults.

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About: Mechanism of hypoxic pulmonary hypertension in newborns and adults. Goto Sponge NotDistinct Permalink

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rdfs:seeAlso	http://www.isvav.cz/projectDetail.do?rowId=GV305/97/S070
Description	Lung vascular injury by chronic hypoxia in adults results in pulmonary hypertension, which is reversible during recovery in air. Perinatal hypoxia , however, induces permanent changes in pulmonary vasculature. The main cause of pulmonary hypertension is the morphologic reconstruction of peripheral arteries and fibroproduction. The aim of the study is to find whether oxidant injury of the muscular matrix by reactive oxygen species participates in this process. Changes may be reversible when induced in adulthood, while perinatal insults may have permanent consequences. After exposure to chronic hypoxia in adult rats and in rats born in hypoxia we will study the mechanisms of production of reactive oxygen species and antioxidant defence. The biochemicalfeatures of injury of the lung tissue will be characterized. We will measure the quantity, types and biochemical structure of collagen in peripheral pulmonary arteries. The change in collagen wilol be related to the proliferative activity of the vascular (en) Poškození plicních cév hypoxií v dospělosti působí plicní hypertenzi, která je obvykle reversibilní. Při poškození v období porodu však změny plicních cév přetrvávají. Hlavní příčinou plicní hypertenze je morfologická rekonstrukce plicních cév. Zmnožuje se hladký sval, stimuluje se produkce pojivových vláken. Cílem studie je prokázat, že jde o důsledek oxidačního poškození pojivové matrix cévní stěny volnými kyslíkovými radikály. Vzniká jako reakce na poškození a toto pak zhoršuje. Oxidace kolagenu můžebýt jedním z důvodů proliferace mesenchymových buněk. Změny mohou být v dospělosti reversibilní, působí-li však hypoxie perinatálně, mohou přetrvávat. Po expozici hypoxií v dospělosti a v období porodu budou studovány mechanismy produkce volných kyslíkových radikálů a antioxidační obranné mechanismy. V periferních plicních cévách bude stanoveno množství, zastoupení jednotlivých typů a změny struktury kolagenu. Bude sledováno jak změna struktury cévních pojivových vláken ovlivňuje proliferací
Title	Mechanism of hypoxic pulmonary hypertension in newborns and adults. (en) Mechanismus vzniku hypoxické plicní hypertenze u novorozených a u dospělých.
skos:notation	GV305/97/S070
http://linked.open...avai/cep/aktivita	Comprehensive projects
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http://linked.open...datumDodatniDoRIV	2003-11-28 (xsd:date)
http://linked.open...i/cep/druhSouteze	VS - Veřejná soutěž ve výzkumu a vývoji
http://linked.open...ep/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open.../cep/fazeProjektu	1174252
http://linked.open...ai/cep/hlavniObor	FA - Kardiovaskulární nemoci včetně kardiochirurgie
http://linked.open...hodnoceniProjektu	V - Vynikající výsledky (s mezinárodním významem apod.). Zároveň byly splněny cíle a předpokládané výsledky uvedené ve smlouvě / rozhodnutí o poskytnutí podpory.
http://linked.open.../cep/klicovaSlova	Neuvedeno. (en)
http://linked.open...ep/partnetrHlavni	2. lékařská fakulta
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http://linked.open...iciPoslednihoRoku	2003
http://linked.open...atUdajeProjZameru	2003
http://linked.open...usZobrazovaneFaze	DUU
http://linked.open...ai/cep/typPojektu	P - Projekt výzkumu a vývoje financovaný ze státního rozpočtu
http://linked.open.../cep/vedlejsiObor	FC - Pneumologie
http://linked.open...jektu+dodavatelem	Výsledky významně rozšiřují současné znalosti o mechanismu vzniku plicní hypertenze. Jde především o radikálové poškození stěny periferních cév na počátku expozice hypoxii. Uplatňují se kyslíkové radikály, oxid dusnatý a produkty jejich vzájemné interakc (cs)
http://linked.open...tniCyklusProjektu	ZBBBBKU
is http://linked.open...vavai/riv/projekt of	Fenfluramine-induced pulmonary vasoconstriction: role of serotonin receptors and potassium channels Evalution of peptide electropherograms by multivariate mathematical - statistical methods Evaluation of peptide electropherograms by multivariate mathematical-statistical methods. I. Principal component analysis. The levels of lipid peroxidation products in red cells of rats exposes to hypoxia and hypoxia with hypercapnia. Long term effects of perinatal hypoxia on the pulmonary circulation Dehydroepiandrosterone sulfate reduces experimental pulmonary hypertension in rats. Dehydroepiandrosterone sulphate reduces chronic hypoxic pulmonary hypertension in rats Comparison of standard capillary and chip separations of sodium dodecylsulfate-protein complexes. Viability of rat aortic smooth muscle cells in cultures on collagen I degraded by matrix metalloproteinase Ultraviolet light-irradiated collagen III modulates expression of cytoskeletal and surface adhesion molecules in rat aortic smooth muscle cells in vitro. Ultraviolet detector response of glycine and alanine homopeptides: Some specific features in capillary electrophoresis. The Effect of Preventive Treatment with ACE Inhibitor Affects Composition of Cardiac Collagen in Hypoxic Rats Mechanizmus rekonstrukce plicního cévního řečiště při chronické hypoxii Long-term Effects of Perinatal Hypoxia on the Pumonary Circualtion: are thay Protective? Unfluence of Macrophages and Macrophyge-Modified Collagen I on the Adhesion and Proliferation of Vascular Smooth Muscle Cells in Culture Protein remodelation of rat cardiovascular system induced by chronic hypoxia is affected by batimastat- inhibitor of collagenolytic activity. Ventilation, EELV and diaphragmatic activity in rats during chronic normobaric hypoxia. Ventilation, EELV and diaphragmatic activity in rats during the early phase of normobaric hypoxia. Ventilatory Responze to Sustained Hypoxia in Carotid Body Denervated Rats A combination of HPLC and capillary electrophoresis to reveal minor changes in posttranslationally modified collagen Adverse pulmonary vascular effects of high dose tricyclic antidepressants: acute and chronic animal studies Adhesion, growth and stress adaptation of vascular smooth muscle cells in cultures on collagen I degraded by matrix metalloproteinases-13. Adhesion, growth and stress adaptation of vascular smooth muscle cells in cultures on collagen I degraded by matrix metalloproteinase-13. Contractility of mesenteric arteries in Prague hereditary hypertensive rats. Hypercapnia inhibits the increase of collagenolytic activity in lungs of hypoxic rats Hypercapnia inhibits the hypoxia-induced collagen breakdown in the walls of peripheral pulmonary arteries Hypoxia increases synthesis of metalloproteinases in isolated rat lung mast cells. Hypercapnia inhibits the increase of collagenolytic activity in lungs of hypoxic rats Gender differences in the role of calcium release from sarcoplasmic reticulum in the pulmonary vascular tone regulation Hypoxic fetoplacental vasoconstriction in humans is mediated by potassium channel inhibition. Prolonged, selective inhibition of inducible nitric oxide synthase (iNOS) in intact rats by addition of L-N6-(1-iminoethyl)lysine (L-NIL) to drinking water Pulmonary vasoconstriction prevents arterial hypoxiemia in isolated rat lungs ventilated with hypoxic gas. Small collagen cleavage fragments present in peripheral pulmonary arteries (PPA) of rats exposed to 4 day hypoxia daispear in chronic hypoxic exposure. Effect of hypercapnia on vascular remodelling induced by chronic hypoxia Increase in the pulmonary vascular tonus induced by 4 days of hypoxia is located in arterial vascular segment Inhibition of radical tissue injury by hypercapnia attenuates the development of hypoxic pulmonary hypertension (HPH) in rats Inducible nitric oxide synthase participates in the mechanism of chronic hypoxic pulmonary hypertension N-acetylcysteine (NAC) but not L-NAME inhibits pulmonary vascular effects of 5 days hypoxia in rats. Possible Role of Matrix Metalloproteinases in Reconstruction of Peripheral Pulmonary Arteries Induced by Hypoxia Inhibitior of Collagenolytic Activity Suppresses Hypoxic Pulmonary Hypertension in Rats Hypoxia Induces Free Radical Damage to Rat Erythrocytes and Spleen: Analysis of the Fluorescent End-products of Lipid Peroxidation Hypoxic Pulmonary Hypertension is Inhibited by Antioxidant N-acetyl cysteine Free Radicals in Rat Lung During and after Hypoxia Influence of macrophages and macrophyge-modified collagen I on the adhesion and proliferation of vascular smooth muscle cells in culture. A possible role of the oxidant tissue injury in the development of hypoxic pulmonary hypertension. Late effects of perinatal hypoxia on pulmonary vessels are gender dependent. Perinatal history of hypoxia leads to lower vascular pressures an hyporeactivity to angiotensin II in isolated lungs of adult rats. Nitric oxide and the regulation of the pulmonary vessels. Ovaries protect adult female rats born in hypoxia from the development of pulmonary hypertension. The role of radicals in the development of hypoxic pulmonary hypertension Role of nitric oxide in the pathogenesis of chronic pulmonary hypertension. The role of matrix metalloproteinases in remodeling of the peripheral pulmonary arterial wall in rats exposed to chronic hypoxia. Biphasis Ventilatory Responze to Hypoxia in Unanesthetized Rats Metalloproteinase inhibition by Batimastat attenuates pulmonary hypertension in chronically hypoxic rats Hypoxická plicní hypertenze interakce pozitivních a negativních působení. Hypercapnia inhibits hypoxic pulmonary hypertension in rats. Hypercapnia prevents blunding of PGF 2a vasoconstriction in rat pulmonary arteries induced by five days of hypoxia. Impairment of hypoxic pulmonary vasoconstriction in mice lacking the voltage-gated potassium channel Kv1.5 Hyperoxia and Recovery from Hypoxia Alter Collagen in Peripheral Pulmonary Arteries Similarly Mechanism of inhibition of lung collagenolytic activity by Batimastat. Mechanism of inhibition of lung collagenolytic activity by Batimastat Sex hormones determine the permanent effects of perinatal hypoxia on the pulmonary circulation Hyperoxia prevents carrageenan-induced enlargement of functional residual lung capacity in rats Gender differences in the long-term effects of perinatal hypoxia on pulmonary circulation in rats Assessment of Exhaled Gases in Ventilated Preterm Infants.
is http://linked.open...vavai/cep/projekt of	http://linked.opendata.cz/resource/domain/vavai/cep/ucast/GV305%2F97%2FS070/1997/ico%3A00023728 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/GV305%2F97%2FS070/1997/ico%3A67985823 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/GV305%2F97%2FS070/1997/orjk%3A11130 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/GV305%2F97%2FS070/1998/ico%3A00023728 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/GV305%2F97%2FS070/1998/ico%3A67985823

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