About: Anti-inflammatory activity of plant quinones     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Projekt, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:seeAlso
Description
  • Scope of this project is the study inhibition of cyclooxygenases (COXs) and lipoxygenases (LOXs) enzymes by plant quinones. COXs and LOXs play key role in regulation of inflammatory diseases, in growth of cancer cells and in other pathological processes in mammalian tissues. Therefore currant research is aimed on searching for dual inhibitors of COX-2 and 5-LOX enzymes. Plant compounds are served as prospective source of these compounds. In vitro enzyme assay monitoring production of prostaglandins and leukotrienes which are products of COX and LOX pathway respectively will be used for tests. Screening of selected plant quinones for COX-1, COX-2 and 5-LOX inhibition and impact of simple derivatization steps on its activity will be carried out during the project solving. For perspective compounds inhibitory concentrations (IC50) will established and selectivity for enzymes will be calculated. Most active compounds will be tested for its toxicity. Moreover, study of mechanism of inhibition will be performed for selected constituents. (en)
  • Cílem projektu je nalezení látek efektivně inhibujících současně COX-2 a 5-LOX, které by mohly sloužit pro vývoj nových bezpečných protizánětlivých léků. Dalším cílem je ověřit vliv jednoduchých derivatizací chinonů na jejich inhibiční aktivitu. U aktivních látek zjištění způsobu inhibice enzymů.
Title
  • Anti-inflammatory activity of plant quinones (en)
  • Protizánětlivá aktivita rostlinných chinonů
skos:notation
  • GP525/09/P528
http://linked.open...avai/cep/aktivita
http://linked.open...kovaStatniPodpora
http://linked.open...ep/celkoveNaklady
http://linked.open...datumDodatniDoRIV
http://linked.open...i/cep/druhSouteze
http://linked.open...ep/duvernostUdaju
http://linked.open.../cep/fazeProjektu
http://linked.open...ai/cep/hlavniObor
http://linked.open...hodnoceniProjektu
http://linked.open...vai/cep/kategorie
http://linked.open.../cep/klicovaSlova
  • rostlinné chinony; cyklooxygenáza; lipoxygenáza; léčivé rostliny (en)
http://linked.open...ep/partnetrHlavni
http://linked.open...inujicichPrijemcu
http://linked.open...cep/pocetPrijemcu
http://linked.open...ocetSpoluPrijemcu
http://linked.open.../pocetVysledkuRIV
http://linked.open...enychVysledkuVRIV
http://linked.open...lneniVMinulemRoce
http://linked.open.../prideleniPodpory
http://linked.open...iciPoslednihoRoku
http://linked.open...atUdajeProjZameru
http://linked.open.../vavai/cep/soutez
http://linked.open...usZobrazovaneFaze
http://linked.open...ai/cep/typPojektu
http://linked.open...ep/ukonceniReseni
http://linked.open...ep/zahajeniReseni
http://linked.open...jektu+dodavatelem
  • The project gone according to plan both in terms of expertise and in terms of disbursement of funds. (en)
  • Řešení projektu proběhlo podle plánu jak z hlediska odborného tak i z hlediska čerpání finančních prostředků. (cs)
http://linked.open...tniCyklusProjektu
http://linked.open.../cep/klicoveSlovo
  • cyklooxygenáza
  • lipoxygenáza
  • rostlinné chinony
is http://linked.open...vavai/riv/projekt of
is http://linked.open...vavai/cep/projekt of
Faceted Search & Find service v1.16.116 as of Feb 22 2024


Alternative Linked Data Documents: ODE     Content Formats:   [cxml] [csv]     RDF   [text] [turtle] [ld+json] [rdf+json] [rdf+xml]     ODATA   [atom+xml] [odata+json]     Microdata   [microdata+json] [html]    About   
This material is Open Knowledge   W3C Semantic Web Technology [RDF Data] Valid XHTML + RDFa
OpenLink Virtuoso version 07.20.3239 as of Feb 22 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 82 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software