About: Role of nitric oxide in the damage of epithelial cells by reactive oxygen metabolites     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Projekt, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:seeAlso
Description
  • Cell damage caused by free radicals plays an important role in the pathogenesis of many animal and human diseases. The main aim of the project is to clarify the role of the nitrite oxide (NO) in epithelial cell damage caused by oxygen free radicals in consequence of oxidative stress. For this purpose appropriate models of epithelial cell lines damage by oxygen free radical donors will be proposed. Physiological changes and changes in intracellular redox state of epithelial cells will be examined afteroxidative stress and after treatment of cell by different concentrations of NO. Arachidonic acid and cyclic guanosin monophosphate signal transduction pathways in effect of NO on epithelial cells in consequence with oxidative stress will be studied with use of specific inhibitors of these signal pathways. Low molecular weight antioxidants N-acetylcysteine and reduced glutathione will be used to clarify mutual effect of NO and oxygen free radicals on epithelial cells. Results of the project will (en)
  • Poçkozenˇ bunŘźněch struktur volněmi radik ly hraje věznamnou roli v patogenezi ýady onemocnŘnˇ zvˇýat a lidˇ. Hlavnˇm cˇlem projektu je objasnit vliv oxidu dusnat‚ho (NO) na poçkozenˇ epiteli lnˇch bunŘk reaktivnˇmi kyslˇkověmi metabolity (RKM) v souvislosti s oxidativnˇm stresem. Pro tento Łźel budou navr§eny vhodn‚ modely poçkozenˇ epiteli lnˇch bunŘźněch liniˇ r…zněmi donory kyslˇkověch radik l…. D le budou analyzov ny fyziologick‚ zmŘny a zmŘny redoxnˇho stavu epiteli lnˇch bunŘk bŘhem oxidativnˇho stresu a po p…sobenˇ r…zněch koncentracˇ NO. Pomocˇ specifickěch inhibitor… bude sledov no zapojenˇ sign lnˇch drah metabolismu kyseliny arachidonov‚ a cyklick‚ho guanosin monofosf tu v p…sobenˇ NO na epiteli lnˇ buĺky v souvislosti s oxidativnˇm stresem. Pro objasnŘnˇ vz jemn‚ho p…sobenˇ NO a RKM budou pou§ity nˇzkomolekul rnˇ antioxidanty N-acetylcystein a redukovaně glutathion. Věsledky projektu pýispŘjˇ k souźasněm znalostem v oblasti z kladnˇho vězkumu p…sobenˇ NO na epiteli lnˇ
Title
  • Role of nitric oxide in the damage of epithelial cells by reactive oxygen metabolites (en)
  • éloha oxidu dusnat‚ho v poçkozenˇ epiteli lnˇch bunŘk reaktivnˇmi kyslˇkověmi metabolity
skos:notation
  • GP524/02/P005
http://linked.open...avai/cep/aktivita
http://linked.open...kovaStatniPodpora
http://linked.open...ep/celkoveNaklady
http://linked.open...datumDodatniDoRIV
http://linked.open...i/cep/druhSouteze
http://linked.open...ep/duvernostUdaju
http://linked.open.../cep/fazeProjektu
http://linked.open...ai/cep/hlavniObor
http://linked.open...hodnoceniProjektu
http://linked.open.../cep/klicovaSlova
  • Neuvedeno. (en)
http://linked.open...ep/partnetrHlavni
http://linked.open...inujicichPrijemcu
http://linked.open...cep/pocetPrijemcu
http://linked.open...ocetSpoluPrijemcu
http://linked.open.../pocetVysledkuRIV
http://linked.open...enychVysledkuVRIV
http://linked.open...iciPoslednihoRoku
http://linked.open...atUdajeProjZameru
http://linked.open.../vavai/cep/soutez
http://linked.open...usZobrazovaneFaze
http://linked.open...ai/cep/typPojektu
http://linked.open.../cep/vedlejsiObor
http://linked.open...jektu+dodavatelem
  • Projekt byl pýedźasnŘ ukonźen na § dost ýeçitele, vzhledem k dlouhodob‚ zahraniźnˇ st §i. 1.a) popis vhodněch koncentracˇ testovaněch l tek indukujˇcˇch snˇ§enˇ proliferace bez zn mek apopt˘zy a d vky indukujˇcˇ apopt˘zu a nekr˘zu, b) menadion byl prok z (cs)
http://linked.open...tniCyklusProjektu
is http://linked.open...vavai/riv/projekt of
is http://linked.open...vavai/cep/projekt of
Faceted Search & Find service v1.16.118 as of Jun 21 2024


Alternative Linked Data Documents: ODE     Content Formats:   [cxml] [csv]     RDF   [text] [turtle] [ld+json] [rdf+json] [rdf+xml]     ODATA   [atom+xml] [odata+json]     Microdata   [microdata+json] [html]    About   
This material is Open Knowledge   W3C Semantic Web Technology [RDF Data] Valid XHTML + RDFa
OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 58 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software