About: Heat shock proteins as biomarkers of exposure to polycyclic aromatic hydrocarbons

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Projekt, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/domain/vavai/Projekt
rdfs:seeAlso	http://www.isvav.cz/projectDetail.do?rowId=GP310/01/P030
Description	A number of exogenous chemical compounds (xenobiotics) continuously affects the human organism, some of them cause the damage of DNA, or proteins. Polycyclic aromatic hydrocarbons (PAHs) are important pollutants, that are adsorbed to respirable air particles (<2.5 u.m) resulted from processes of incomplete combustion. These xenobiotics can be received even by the food chain. Some of PAHs have been identified as possible carcinogens to humans. Biomarkers are defined as indicators of exposure and effect of xenobiotics on human organism. Heat shock proteins have been found to be very sensitive biomarkers of environmental pollution, hsp32 protein is important for the degradation of heme to bilirubin; its expression is induced for example by cytochrome P450. This cytochrome is induced after the exposure to PAHs. hsp70 proteins help to repair denatured, or abnormal proteins, they also stabilize proteins. The purposes of the project: to investigate, if hsp32 and hsp70 proteins are expressed as (en) Lidskě organismus je kontinu lnŘ vystavov n p…sobeni cel‚ ýady exogennˇch chemickěch l tek (xenobiotik), z nich§ mnoh‚ poçkozujˇ DNA nebo proteiny. Mezi věznamn‚ çkodliviny patýˇ i polycyklick‚ aromatick‚ uhlovodˇky (PAU), kter‚ jsou v ovzduçˇ adsorbov nna respirabilnˇ ź stice (<2,5 mě m), jejich§ zdrojem jsou r…zn‚ procesy nedokonal‚ho spalov nˇ. Tyto cizorod‚ l tky mohou bět pýijˇm ny i potravinověm ýetŘzcem. Mnoh‚ PAU se ýadˇ mezi potenci lnˇ karcinogeny pro źlovŘka. Biomarkery jsou indik tory, kter‚umo§ĺujˇ sledovat vliv xenobiotik na §ivě organismus. Proteiny teplotnˇho çoku (hsp) mohou bět citlivěmi biomarkery zneźiçtŘn‚ho prostýedˇ. Protein hsp32 se podˇlˇ na pýemŘnŘ hemu na bilirubin; jeho exprese je indukov na napr. cytochromem P450. Tento cytochrom je indukov n po p…sobenˇ PAU. Proteiny skupiny hsp70 se uplatĺujˇ pýi opravŘ denaturovaněch nebo jinak poçkozeněch protein… a mohou se tak‚ podˇlet na jejich stabilizaci. Cˇle navrhovan‚ho projektu: a) prok zat expresi protein… hsp32 a hsp70
Title	Heat shock proteins as biomarkers of exposure to polycyclic aromatic hydrocarbons (en) Proteiny teplotnˇho çoku jako biomarkery expozice polycyklickěm aromatickěm uhlovodˇk…m
skos:notation	GP310/01/P030
http://linked.open...avai/cep/aktivita	Post-graduate (doctorate) grants
http://linked.open...kovaStatniPodpora	http://linked.opendata.cz/resource/domain/vavai/projekt/GP310%2F01%2FP030/celkovaStatniPodpora
http://linked.open...ep/celkoveNaklady	http://linked.opendata.cz/resource/domain/vavai/projekt/GP310%2F01%2FP030/celkoveNaklady
http://linked.open...datumDodatniDoRIV	2009-06-15 (xsd:date)
http://linked.open...i/cep/druhSouteze	VS - Veřejná soutěž ve výzkumu a vývoji
http://linked.open...ep/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open.../cep/fazeProjektu	1163414
http://linked.open...ai/cep/hlavniObor	EB - Genetika a molekulární biologie
http://linked.open...hodnoceniProjektu	U - Uspěl podle zadání, tj. byly splněny cíle a jeho předpokládané výsledky uvedené ve smlouvě / rozhodnutí o poskytnutí podpory
http://linked.open.../cep/klicovaSlova	Neuvedeno. (en)
http://linked.open...ep/partnetrHlavni	Ústav experimentální medicíny Akademie věd České republiky, v. v. i.
http://linked.open...inujicichPrijemcu	0 (xsd:int)
http://linked.open...cep/pocetPrijemcu	1 (xsd:int)
http://linked.open...ocetSpoluPrijemcu	0 (xsd:int)
http://linked.open.../pocetVysledkuRIV	2 (xsd:int)
http://linked.open...enychVysledkuVRIV	2 (xsd:int)
http://linked.open...iciPoslednihoRoku	2003
http://linked.open...atUdajeProjZameru	2003
http://linked.open.../vavai/cep/soutez	SGA02002GA-PD
http://linked.open...usZobrazovaneFaze	DUS
http://linked.open...ai/cep/typPojektu	P - Projekt výzkumu a vývoje financovaný ze státního rozpočtu
http://linked.open.../cep/vedlejsiObor	FN - Epidemiologie, infekční nemoci a klinická imunologie
http://linked.open...jektu+dodavatelem	Projekt byl pýedźasnŘ ukonźen na § dost ýeçitele, vzhledem k dlouhodob‚ zahraniźnˇ st §i. V r mci projektu byla sledov na exprese dvou protein… tepeln‚ho çoku a to Hsp32 a Hsp 70. Pýedpokl dalo se, §e exprese tŘchto molekul m…§e bět vyu§ita jako biomolek (cs)
http://linked.open...tniCyklusProjektu	ZBS
is http://linked.open...vavai/riv/projekt of	The effect of acrylonitrile exposure on the expression of p53 and p21WAF1 proteins in the blood plasma of occupationally exposed workers and in human diploid lung fibroblasts. Heat shock proteins hsp32 and hsp70 as biomarkers of an early response? In vitro induction of heat shock proteins after exposure of cell culture to carcinogenic compounds and their real mixtures.
is http://linked.open...vavai/cep/projekt of	http://linked.opendata.cz/resource/domain/vavai/cep/ucast/GP310%2F01%2FP030/2001/ico%3A68378041 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/GP310%2F01%2FP030/2002/ico%3A68378041 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/GP310%2F01%2FP030/2003/ico%3A68378041

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