About: Startle reaction and prepulse inhibition in human with latent toxoplasmosis

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rdfs:seeAlso	http://www.isvav.cz/projectDetail.do?rowId=GAP303/11/1398
Description	Prevalence of latent toxoplasmosis in Czech population is about 30%. This parasitosis is medically considered asymptomatic although recent research brought growing evidence of behavioral and physiological changes in human caused by presence of the parasite. In this study, we aim to focus on possible link between latent toxoplasmosis and schizophrenia using commonly utilized method of prepulse inhibition of the startle reaction. This link has been lately pointed upon multiple times although the studies mostly claimed only that a significant correlation between increased numbers of antibodies against Toxoplasma gondii and increased prevalence of schizophrenia exists. Our aim is to reveal whether there are any signs of impaired signal processing in human with latent toxoplasmosis similar to those in schizophrenia patients. Thus we aim to contribute to the understanding of the mechanism of the latent toxoplasmosisimpact on human CNS and possibly suggest the way of assessing probability of schizophrenia outburst in toxoplasma-positive patients with other predispositions for schiophrenia. (en) Latentní toxoplasmosa, jejíž prevalence v české populaci činí asi 30%, je z medicínského hlediska stále považována za bezpříznakové onemocnění. V poslední době však přibývá důkazů o možných vlivech jejího původce, kokcidie Toxoplasma gondii, na behaviorální i fyziologické změny. V této studii bychom se chtěli zaměřit na možné spojení mezi latentní toxoplasmosou a onemocněním schizofrenií, a to prostřednictvím běžně používané metody měření prepulsní inhibice úlekové reakce. Na tuto souvislost již bylo v posledních letech několikrát poukázáno, avšak většinou šlo o pouhé konstatování vztahu mezi zvýšeným výskytem protilátek proti kokcidii v séru a zvýšeným rizikem propuknutí schizofrenního onemocnění. Naším cílem je otestovat, zda se narušení zpracovávání informací v CNS schizofrenních pacientů nevyskytuje i u osob s latentní toxoplasmosou. Tím bychom chtěli přispět k pochopení mechanismů působení toxoplasmosy na lidský nervový systém, a naznačit možnou cestu k odhadu rizika propuknutní schizofrenie u toxoplasma-pozitivních pacientů s dalšími predispozicemi ke vzniku tohoto onemocnění.
Title	Startle reaction and prepulse inhibition in human with latent toxoplasmosis (en) Úleková reakce a prepulsní inhibice u lidí s latentní toxoplasmosou
skos:notation	GAP303/11/1398
http://linked.open...avai/cep/aktivita	Standard projects
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http://linked.open...i/cep/druhSouteze	VS - Veřejná soutěž ve výzkumu a vývoji
http://linked.open...ep/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open.../cep/fazeProjektu	100777428
http://linked.open...ai/cep/hlavniObor	FH - Neurologie, neurochirurgie, neurovědy
http://linked.open...vai/cep/kategorie	ZV - Základní výzkum
http://linked.open.../cep/klicovaSlova	Toxoplasma gondii startle reaction prepulse inhibition schizophrenia (en)
http://linked.open...ep/partnetrHlavni	Přírodovědecká fakulta
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http://linked.open.../prideleniPodpory	http://linked.opendata.cz/resource/domain/vavai/cep/prideleniPodpory/P303-11-1398
http://linked.open...iciPoslednihoRoku	2015
http://linked.open...atUdajeProjZameru	2015
http://linked.open.../vavai/cep/soutez	SGA02011GA-ST
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http://linked.open...tniCyklusProjektu	ZBBBK
is http://linked.open...vavai/riv/projekt of	Difference of neuro- and immunomodulatory steroids and selected hormone and lipid concentrations between Toxoplasma-free and Toxoplasma-infected but not CMV-free and CMV-infected schizophrenia patients Does the prevalence of latent toxoplasmosis and frequency of Rhesus-negative subjects correlate with the nationwide rate of traffic accidents? Justine Effect: Punishment of the Unduly Self-Sacrificing Cooperative Individuals Fatal attraction phenomenon in humans – cat odour attractiveness increased for Toxoplasma-infected men while decreased for infected women Toxoplasmosis can be a sexually transmitted infection with serious clinical consequences. Not all routes of infection are created equal Toxoplasmosis - A Global Threat. Correlation of Latent Toxoplasmosis with Specific Disease Burden in a Set of 88 Countries Differences in onset of disease and severity of psychopathology between toxoplasmosis-related and toxoplasmosis-unrelated schizophrenia Influence of latent Toxoplasma infection on human personality, physiology and morphology: pros and cons of the Toxoplasma-human model in studying the manipulation hypothesis How and why Toxoplasma makes us crazy Higher Extraversion and Lower Conscientiousness in Humans Infected with Toxoplasma Latent toxoplasmosis reduces gray matter density in schizophrenia but not in controls: Voxel-based-morphometry (VBM) study Toxoplasmosis-associated difference in intelligence and personality in men depends on their rhesus blood group but not ABO blood group The Distribution of Toxoplasma gondii Cysts in the Brain of a Mouse with Latent Toxoplasmosis: Implications for the Behavioral Manipulation Hypothesis The relation of cortisol and sex hormone levels to results of psychological, performance, IQ and memory tests in military men and women Why do some women prefer submissive men? Hierarchically disparate couples reach higher reproductive success in European urban humans Contrasting Effect of Prepulse Signals on Performance of Toxoplasma-Infected and Toxoplasma-Free Subjects in an Acoustic Reaction Times Test
is http://linked.open...vavai/cep/projekt of	http://linked.opendata.cz/resource/domain/vavai/cep/ucast/GAP303%2F11%2F1398/2011/orjk%3A11310 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/GAP303%2F11%2F1398/2012/orjk%3A11310 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/GAP303%2F11%2F1398/2013/orjk%3A11310 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/GAP303%2F11%2F1398/2014/orjk%3A11310 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/GAP303%2F11%2F1398/2015/orjk%3A11310

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