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| Description
| - Magnetic resonance imaging (MRI) is one of the most important medicinal diagnostic methods. For a better resolution of the images, the substances called contrast agents (CAs) are often administered. They are mostly Gd3+-complexes, which contain one coordinated water molecule. CAs increase relaxation rate of the excited state of water hydrogen nuclei present in the studied object. It leads to increase in the measured signal intensity. In the frame of this project, potentially more efficient contrast agents will be prepared, containing two coordinated water molecules. Complexes of Mn2+ ion will be also studied. They can serve as the CAs, taking the advantage of lower toxicity of Mn2+ comparing to Gd3+, and of generally faster water exchange rate. Derivatives containing fluorine will be prepared. The fluorine nuclei can be easily detected in MRI scanner. The advantage is zero background of this nucleus in the living organisms. The systems bringing the possibility of chemical exchange saturation transfer effect (CEST) will be studied. In MRI, their main advantage is a high specificity. (en)
- Magnetická rezonanční tomografie (MRI) je jednou z nejvýznamnějších medicínských diagnostických metod. Pro zlepšení kontrastu v řezech snímaných pomocí MRI jsou využívány tzv. kontrastní látky. Jedná se nejčastěji o komplexy iontu Gd3+, ke kterému je koordinována jedna molekula vody. Kontrastní látka urychluje relaxaci excitovaného stavu jader vodíku v molekulách vody ve studovaném objektu, čímž zvyšuje intenzitu měřeného signálu. V rámci tohoto projektu budou připraveny potenciálně účinnější kontrastní látky obsahující dvě koordinované molekuly vody k centrálnímu iontu Gd3+. Budou studovány komplexy Mn2+, které mohou též sloužit jako kontrastní látky; jejich výhodou je nižší toxicita Mn2+ v porovnání s Gd3+, a též obecně rychlejší výměna koordinované molekuly vody. Budou připraveny deriváty obsahující fluor, který může být detekován pomocí MRI tomografu. Výhodou je nulové pozadí (nulový obsah fluoru v organismu). Budou studovány systémy saturující signál vody díky chemické výměně s labilními protony vázanými v kontrastní látce (tzv. CEST-kontrastní látky); výhodou je specificita.
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| Title
| - Novel classes of contrast agents for magnetic resonance imaging (en)
- Nové třídy kontrastních látek pro tomografii magnetické rezonance
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| skos:notation
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| http://linked.open...avai/cep/aktivita
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| http://linked.open...kovaStatniPodpora
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| http://linked.open...ep/celkoveNaklady
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| http://linked.open...datumDodatniDoRIV
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| http://linked.open...i/cep/druhSouteze
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| http://linked.open...ep/duvernostUdaju
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| http://linked.open.../cep/fazeProjektu
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| http://linked.open...ai/cep/hlavniObor
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| http://linked.open...vai/cep/kategorie
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| http://linked.open.../cep/klicovaSlova
| - gadolinium manganese fluorine MRI PARACEST (en)
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| http://linked.open...ep/partnetrHlavni
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| http://linked.open...inujicichPrijemcu
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| http://linked.open...cep/pocetPrijemcu
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| http://linked.open...ocetSpoluPrijemcu
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| http://linked.open.../pocetVysledkuRIV
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| http://linked.open...enychVysledkuVRIV
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| http://linked.open...lneniVMinulemRoce
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| http://linked.open.../prideleniPodpory
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| http://linked.open...iciPoslednihoRoku
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| http://linked.open...atUdajeProjZameru
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| http://linked.open.../vavai/cep/soutez
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| http://linked.open...usZobrazovaneFaze
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| http://linked.open...ai/cep/typPojektu
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| http://linked.open...ep/ukonceniReseni
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| http://linked.open.../cep/vedlejsiObor
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| http://linked.open...ep/zahajeniReseni
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| http://linked.open...tniCyklusProjektu
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| is http://linked.open...vavai/riv/projekt
of | - Tris(phosphonomethyl) Cyclen Derivatives: Synthesis, Acid-Base Properties and Complexation Studies with Cu2+ and Zn2+ Ions
- Tris(phosphonomethyl)cyclen Derivatives: Thermodynamic Stability, Kinetics, Solution Structure, and Relaxivity of Ln(3+) Complexes
- Bis(phosphonate)-Building Blocks Modified with Fluorescent Dyes
- Modification of Nanocrystalline TiO2 with Phosphonate- and Bis(phosphonate)-Bearing Macrocyclic Complexes: Sorption and Stability Studies
- Lanthanide(III) Complexes That Contain a Self-Immolative Arm: Potential Enzyme Responsive Contrast Agents for Magnetic Resonance Imaging
- Dissociation kinetics of Mn(2+) complexes of NOTA and DOTA
- Gadolinium complexes of monophosphinic acid DOTA derivatives conjugated to cyclodextrin scaffolds: efficient MRI contrast agents for higher magnetic fields
- Mn(2+) complexes of 1-oxa-4,7-diazacyclononane based ligands with acetic, phosphonic and phosphinic acid pendant arms: Stability and relaxation studies
- Mn(2+) Complexes with 12-Membered Pyridine Based Macrocycles Bearing Carboxylate or Phosphonate Pendant Arm: Crystallographic, Thermodynamic, Kinetic, Redox, and (1)H/(17)O Relaxation Studies
- Gadolinium- and manganite-based contrast agents with fluorescent probes for both magnetic resonance and fluorescence imaging of pancreatic islets: a comparative study
- Lanthanide(III) complexes of aminoethyl-DO3A as PARACEST contrast agents based on decoordination of the weakly bound amino group
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| is http://linked.open...vavai/cep/projekt
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