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| Description
| - The project builds on experiences and investigator team experimental results obtained in the field of bioinorganic chemistry and nanomaterials. The project objectives are the synthesis and characterization of hybrid molecular-crystalline nanostructures with functionalized nanocrystalline carrier based on iron oxides (maghemite, magnetite, ferrites) surface-modified by suitable biocompatible phases, which can be used for bonding of biologically active complexes structurally derived from cisplatin, carboplatin and oxaliplatin and involving N6-(benzyl)adenine, 9-deazaguanine or O6-(alkyl-substituted)guanine N-donor ligand derivatives or magnetically interesting compound (e.g. molecular magnets or switches). The mentioned hybrid systems with biologically active compounds can be used in the field of targeted drug deliveries. The systems with magnetic complexes can serve as contrast agents of the MRI diagnostic applications or as memory and recording media. The project aim will also be the optimization of the system preparations towards further possible medicinal and material applications. (en)
- Projekt staví na zkušenostech a experimentálních výsledcích řešitelského týmu dosažených v oblastech bioanorganické chemie a nanomateriálů a jeho cílem je syntéza a kompletní charakterizace hybridních molekulárně-krystalických nanostruktur s funkcionalizovaným nanokrystalickým nosičem na bázi oxidů železa (maghemit, magnetit, ferity) povrchově modifikovaných vhodnými biokompatibilními fázemi, které jsou využitelné pro navázání biologicky aktivních Pt(II)-komplexů strukturně odvozených cisplatiny, karboplatiny a oxaliplatiny, ve kterých je N-donorový ligand nahrazen např. deriváty N6-(benzyl)adeninu, 9-deazaguaninu nebo O6-(alkyl)guaninu, případně magneticky zajímavých sloučenin (např. molekulové magnety a přepínače). Zmíněné hybridní systémy s biologicky aktivními komplexy mohou najít uplatnění v oblasti cíleného transportu léčiv. Systémy s magnetickými komplexy pak jako kontrastní látky v diagnostických MRI aplikacích nebo jako paměťová a záznamová média. Předmětem projektu bude také optimalizace přípravy výše zmíněných systémů směrem k možným medicínským či materiálovým aplikacím.
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| Title
| - Functionalized Magnetic Carriers Based on Iron Oxide Nanoparticles with Bonded Biologically Active or Magnetically Interesting Compounds (en)
- Funkcionalizované magnetické nosiče na bázi nanočástic oxidů železa s navázanými biologicky aktivními nebo magneticky zajímavými sloučeninami
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| http://linked.open...avai/cep/aktivita
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| http://linked.open...kovaStatniPodpora
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| http://linked.open...ep/celkoveNaklady
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| http://linked.open...datumDodatniDoRIV
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| http://linked.open...i/cep/druhSouteze
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| http://linked.open...ep/duvernostUdaju
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| http://linked.open.../cep/fazeProjektu
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| http://linked.open...ai/cep/hlavniObor
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| http://linked.open...hodnoceniProjektu
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| http://linked.open...vai/cep/kategorie
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| http://linked.open.../cep/klicovaSlova
| - Iron oxide nanoparticles Magnetic carriers Functionalization Biologically active compounds Molecular magnets. (en)
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| http://linked.open...ep/partnetrHlavni
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| http://linked.open...inujicichPrijemcu
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| http://linked.open...cep/pocetPrijemcu
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| http://linked.open...ocetSpoluPrijemcu
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| http://linked.open.../pocetVysledkuRIV
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| http://linked.open...enychVysledkuVRIV
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| http://linked.open...lneniVMinulemRoce
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| http://linked.open.../prideleniPodpory
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| http://linked.open...iciPoslednihoRoku
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| http://linked.open...atUdajeProjZameru
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| http://linked.open.../vavai/cep/soutez
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| http://linked.open...usZobrazovaneFaze
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| http://linked.open...ai/cep/typPojektu
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| http://linked.open...ep/ukonceniReseni
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| http://linked.open.../cep/vedlejsiObor
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| http://linked.open...ep/zahajeniReseni
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| http://linked.open...jektu+dodavatelem
| - The project showed excellent results providing a very high number of uotputs– 23 publications and 3 patents. The investigation significantly contributed to the knowledge in the studied research areas related to biologically active Pt and Cu coordination compounds, magnetically interesting compounds and to the hybrid nanocomposites containing magnetic particles coated with therapeutical agents. (en)
- Projekt byl řešen excelentním způsobem,o čemž svědčí neobvykle vysoký počet výstupů-23 publikací a 3 patenty. Získané výsledky výrazně přispěly ke stavu poznání ve studovaných tematikách, týkajících se biologicky aktivních Pt a Cu koordinačních sloučenin, magneticky zajímavých sloučenin a hybridních nanokompozitů, obsahujících magnetické částice pokryté funkcionalizovanými terapeutickými činidly. (cs)
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| http://linked.open...tniCyklusProjektu
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| is http://linked.open...vavai/riv/projekt
of | - Platinum(II) Oxalato Complexes Involving Adenosine-Based N-Donor Ligands: Synthesis, Characterization and Cytotoxicity Evaluation
- Pharmacological and molecular effects of platinum(II) complexes involving 7-azaindole derivatives.
- Investigation of Magnetic Exchange Pathways in Heterotrinuclear Manganese(III) Schiff Base Complexes Involving Tetrathiocyanidoplatinate(II) Bridges
- Tuning of the Critical Temperature in Iron(II) Spin-Crossover Materials Based on Bridging Polycyanidometallates: Pentacyanidonitrosylferrate(II) and Hexacyanidoplatinate(IV)
- Tuning of spin crossover behaviour in iron(III) complexes involving pentadentate Schiff bases and pseudohalides
- A dinuclear manganese(II) complex {[Na-2(H2O)(4)Mn-2(u-pmtz)(4)(NCS)(2)].chi H2O)(n) with 5-(pyrimidyl)tetrazolato bridges involved in 1D ladder-like chains: Synthesis, X-ray structure, magnetic properties and DFT calculations
- A new family of Fe(2)Ln complexes built from mononuclear anionic Schiff base subunits
- Structural and magnetic characterizations of the first manganese(III) Schiff base complexes involving hexathiocyanidoplatinate(IV) bridges
- Crystal Water Molecules as Magnetic Tuners in Molecular Metamagnets Exhibiting Antiferro-Ferro-Paramagnetic Transitions
- Towards a better understanding of magnetic exchange mediated by hydrogen bonds in Mn(III)/Fe(III) salen-type supramolecular dimers
- 4-Aminobenzoic Acid-Coated Maghemite Nanoparticles as Potential Anticancer Drug Magnetic Carriers: A Case Study on Highly Cytotoxic Cisplatin-Like Complexes Involving 7-Azaindoles
- Mixed-Valence Heptanuclear Iron Complexes with Ferromagnetic Interaction
- Cobalt(III) Schiff-base cyanido complex usable as a ligand in preparation of heterobimetallic Co(III)-Fe(III) building blocks
- Fe3O4 Nanocrystals Tune the Magnetic Regime of the Fe/Ni Molecular Magnet: A New Class of Magnetic Superstructures
- Synthesis, characterization, DNA interaction and cleavage, and in vitro cytotoxicity of copper(II) mixed-ligand complexes with 2-phenyl-3-hydroxy-4(1H)-quinolinone
- Anion driven modulation of magnetic intermolecular interactions and spin crossover properties in an isomorphous series of mononuclear iron(III) complexes with a hexadentate Schiff base ligand
- Dichlorido complexes of platinum with 7-azaindole derivatives, method of their preparation and application of these complexes as drugs in antitumor therapy
- Dichlorido komplexy platiny s halogenderiváty 7-azaindolu a použití těchto komplexů jako léčiv v protinádorové terapii
- How to modify 7-azaindole to form cytotoxic Pt(II) complexes: Highly in vitro anticancer effective cisplatin derivatives involving halogeno-substituted 7-azaindole
- Thermal decomposition of [Co(en)3][Fe(CN)6]?2H2O: Topotactic dehydration process, valence and spin exchange mechanism elucidation
- 5-Aminotetrazole induces spin crossover in iron(III) pentadentate Schiff base complexes: experimental and theoretical investigations
- Synthesis, Characterization and in Vitro Antitumor Activity of Platinum(II) Oxalato Complexes Involving 7-Azaindole Derivatives as Coligands
- Cisplatin and oxaliplatin derivatives involving 7-azaindole: Structural characterisations
- In vitro cytotoxicity, DNA cleavage and SOD-mimic activity of copper(II) mixed-ligand quinolinonato complexes
- Utilization of the dichlorido complexes of platinum with 7-azaindole halogeno-derivatives for the preparation of drugs for the treatment of tumour diseases
- N6-Benzyladenosine Derivatives as Novel N-Donor Ligands of Platinum(II) Dichlorido Complexes
- Slow Magnetic Relaxation in Octahedral Cobalt(II) Field-Induced Single-Ion Magnet with Positive Axial and Large Rhombic Anisotropy
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| is http://linked.open...vavai/cep/projekt
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