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Description
  • This project aims at deciphering the signaling pathways by which cAMP modulates immune system functions and provokes impairment of anti bacterial immunity. We found that elevation of cytosolic cAMP in macrophages causes rapid disorganization of actin cyto (en)
  • Cílem tohoto projektu je identifikovat signální dráhy, jimiž cAMP moduluje buněčné funkce imunitního systému a potlačuje tak antibakteriální imunitu. Nedávno jsme pozorovali, že zvýšení cytosolické hladiny cAMP vede u fagocytů k rychlé dezorganizaci aktin
Title
  • Mechanisms underlying modulation of immune cell functions by cAMP (en)
  • Mechanismy jimiž cAMP moduluje funkce buněk imunitního systému
skos:notation
  • GA310/08/0447
http://linked.open...avai/cep/aktivita
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  • 3; ́; 5; ́-cyclic; adenosine; monophosphate; cAMP; Rho; family; GTPases; actin; cytoskeleton; bactericidal; functions; antigenic; presentation; phagocytosis; macropinocytosis; oxidative; burst (en)
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http://linked.open...inujicichPrijemcu
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  • Byly objasněny mechanismy, které narušují funkci dendritických buněk a fagocytů při infekci bakterií Bordetella pertussis. Plánované cíle byly splněny a získané výsledky byly publikovány ve 12 článcích zveřejněných v časopisech s IF. Výsledkem byl rovněž 1 patent. Splnění cílů projektu vynikajícím způsobem. (cs)
  • Molecular mechanisms paralyzing the function of dendritic cells and phagocytes in course of Bordetella pertussis infection were clarified. Planed aims were completed, results were presented in 12 papers published in journals with IF and 1 patent. Excellent realization of grant project. (en)
http://linked.open...tniCyklusProjektu
http://linked.open.../cep/klicoveSlovo
  • 3
  • 5
  • GTPases
  • Rho
  • actin
  • adenosine
  • antigenic
  • bactericidal
  • cAMP
  • cytoskeleton
  • family
  • functions
  • macropinocytosis
  • monophosphate
  • oxidative
  • phagocytosis
  • presentation
  • ́
  • ́-cyclic
is http://linked.open...vavai/riv/projekt of
is http://linked.open...vavai/cep/projekt of
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