About: Pharmacological implications of the interplay between inducible heme oxygenase/carbon monoxide and nitric oxide synthase/nitric oxide systems in liver     Goto   Sponge   NotDistinct   Permalink

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  • The interaction of heme oxygenase/carbon monoxide and nitric-oxide synthase/nitric oxide systems is noteworthy. Understanding the mutual regulatory mechanisms of CO and NO in hepatocyte injury will provide important clues to the diagnosis and treatment of liver damage. The cascade of events as affected by both CO and NO signaling in the liver yet has to be further investigated. In this research project, the investigators will look for new findings related to pharmacological modulation of endogenous CO and NO in the liver with consequent beneficial or detrimental effects. The latter two gases mutual cross talk will be addressed with an emphasis on the signaling pathways involved and downstream targets that trigger the action of these gases in the liver. To achieve this research purpose, various cellular, biochemical, molecular, morphological and in vivo approaches will be adopted in the present study. The research team is, therefore, integrating investigators from a number of biomedical areas. It is conceivable that the transference of our knowledge on the physiology/biology of CO/NO in the liver (gasotransmitters CO/NO) to pharmacological and therapeutic applications is expected to be encouraged.  (en)
  • Cílem je hledání nových zjištění ve vztahu k farmakologické modulaci gas-transmiterů (endogenní CO a NO) v játrech s následnými prospěšnými nebo škodlivými účinky. Lze si představit, že získané výsledky v oblasti úlohy CO/NO v játrech budou mít potenciální farmakologické či terapeutické uplatnění.
Title
  • Pharmacological implications of the interplay between inducible heme oxygenase/carbon monoxide and nitric oxide synthase/nitric oxide systems in liver (en)
  • Farmakologické důsledky vzájemných vztahů systémů hemoxygenasa/oxid uhelnatý a synthasa oxidu dusnatého/oxid dusnatý po jejich indukci v játrech
skos:notation
  • GA305/09/0004
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  • hepatoprotekce; hepatotoxicita; resveratrol; hepatocyty; hemoxygenasa-1; oxid uhelnatý; oxid dusnatý (en)
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  • The project gone according to plan both in terms of expertise and in terms of disbursement of funds. (en)
  • Řešení projektu proběhlo podle plánu jak z hlediska odborného tak i z hlediska čerpání finančních prostředků. (cs)
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  • hemoxygenasa-1
  • hepatocyty
  • hepatotoxicita
  • oxid uhelnatý
  • resveratrol
  • hepatoprotekce
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