About: Disp3: A potential role in the self renewal and differentiation of neural stem cells

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About: Disp3: A potential role in the self renewal and differentiation of neural stem cells Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Projekt, within Data Space : linked.opendata.cz associated with source document(s)

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rdfs:seeAlso	http://www.isvav.cz/projectDetail.do?rowId=GA204/09/1905
Description	Disp3 is a sterol-sensing domain-containing protein that is related to the family of Dispatched proteins. Expression profiling of Disp3 revealed predominant expression in the brain and retina. DISP3 was found to co-localize with cholesterol in the ER and upon overexpression induced lipid droplet formation. We have identified two neural stem cell lines that highly express Disp3. Disp3 expression is positively regulated by T3 treatment and upon differentiation the level of Disp3 dramatically changes suggesting Disp3 may modulate self-renewal or differentiation. Brain tumors such as medulloblastoma are believed to arise from neural precursor cells. Analysis of a small number of primary tumors revealed very high expression of Disp3 suggesting this protein is important for their pathogenesis. We will conduct RNAi and overexpression studies to determine the role of Disp3 in neural stem cell maintenance. We will also create Disp3 transgenic mice to determine the neural specific effects of Disp3 overexpression on lipid homeostasis and the onset of neurodegenerative disease. (en) 1. Jaká je úloha DISP3 v sebeobnově a diferenciaci neurálních kmenových buněk? 2. Existuje korelace mezi expresí DISP3 a patogenezí nádorů mozku? 3. Jaký je vliv deregulované exprese DISP3 na fyziologii mozku? Existuje korelace mezi expresí DISP3, homeostázou lipidů a neurodegenerativními onemocnění
Title	Disp3: A potential role in the self renewal and differentiation of neural stem cells (en) Disp3: potenciální úloha v sebeobnově a diferenciaci neurálních kmenových buněk
skos:notation	GA204/09/1905
http://linked.open...avai/cep/aktivita	Standard projects
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http://linked.open...ep/celkoveNaklady	http://linked.opendata.cz/resource/domain/vavai/projekt/GA204%2F09%2F1905/celkoveNaklady
http://linked.open...datumDodatniDoRIV	2012-03-30 (xsd:date)
http://linked.open...i/cep/druhSouteze	VS - Veřejná soutěž ve výzkumu a vývoji
http://linked.open...ep/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open.../cep/fazeProjektu	82121671
http://linked.open...ai/cep/hlavniObor	EB - Genetika a molekulární biologie
http://linked.open...vai/cep/kategorie	ZV - Základní výzkum
http://linked.open.../cep/klicovaSlova	neurální kmenové buňky; rakovina; neurodegenerativní onemocnění; sebeobnova; diferenciace; cholester (en)
http://linked.open...ep/partnetrHlavni	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...inujicichPrijemcu	0 (xsd:int)
http://linked.open...cep/pocetPrijemcu	1 (xsd:int)
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http://linked.open.../pocetVysledkuRIV	2 (xsd:int)
http://linked.open...enychVysledkuVRIV	2 (xsd:int)
http://linked.open...lneniVMinulemRoce	2010-04-08 (xsd:date)
http://linked.open.../prideleniPodpory	http://linked.opendata.cz/resource/domain/vavai/cep/prideleniPodpory/204%2F09%2F1905
http://linked.open...iciPoslednihoRoku	2011
http://linked.open...atUdajeProjZameru	2011
http://linked.open.../vavai/cep/soutez	SGA02009GA-ST
http://linked.open...usZobrazovaneFaze	DRRVB
http://linked.open...ai/cep/typPojektu	P - Projekt výzkumu a vývoje financovaný ze státního rozpočtu
http://linked.open...ep/ukonceniReseni	2012-12-31 (xsd:date)
http://linked.open.../cep/vedlejsiObor	EA - Morfologické obory a cytologie FH - Neurologie, neurochirurgie, neurovědy
http://linked.open...ep/zahajeniReseni	2009-01-01 (xsd:date)
http://linked.open...tniCyklusProjektu	ZBB
http://linked.open.../cep/klicoveSlovo	diferenciace neurodegenerativní onemocnění rakovina sebeobnova neurální kmenové buňky
is http://linked.open...vavai/riv/projekt of	Synthesis and evaluation of 17 alpha-(carboranylalkyl)estradiols as ligands for estrogen receptors alpha and beta Synthesis of ferrocenestrone: the first metallocene based steroid analogue
is http://linked.open...vavai/cep/projekt of	http://linked.opendata.cz/resource/domain/vavai/cep/ucast/GA204%2F09%2F1905/2009/ico%3A68378050 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/GA204%2F09%2F1905/2010/ico%3A68378050 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/GA204%2F09%2F1905/2011/ico%3A68378050

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