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Description
| - The development of a suitable methodology for configuration determination of chiral biologically active compounds containing sulfur, nitrogen, or phosphorus atom as a chiral center (sulfoxides, N-oxides, phosphine oxides, phosphinates and phosphonates). The combination of NMR experiments in solution and in solid state with quantum chemical calculations (geometry optimization, calculation of NMR chemical shifts and spin-spin coupling constants) will be used. We would like to explore the effects of magnetic anisotropy of S-O, N-O and P=O functional groups on chemical shifts and coupling constants of the other atoms in the molecule. In the frame of the project we would like to investigate geminal coupling constants J(P-C-C) and J(P-C-H) and their dependence on the structure and configuration of modified nucleotide phosphonates containing an asymmetric carbon in the neighboring position to the phosphorus atom. (en)
- Vypracování vhodné metodiky pro stanovení konfigurace chirálních sloučenin obsahujících jako chirální centrum atom síry, dusíku nebo fosforu (sulfoxidy, N-oxidy, fosfinoxidy, fosfináty a fosfonáty). Aplikace metodiky u biologicky aktivních látek.
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Title
| - Development of methods for configuration determination at chiral sulfur, nitrogen or phosphorus atom using NMR spectroscopy and ab initio calculations (en)
- Vývoj metody stanovení konfigurace na chirálních centrech obsahujících atom síry, dusíku nebo fosforu pomocí NMR spektroskopie a ab initio výpočtů
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skos:notation
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http://linked.open...avai/cep/aktivita
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http://linked.open...kovaStatniPodpora
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http://linked.open...ep/celkoveNaklady
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http://linked.open...datumDodatniDoRIV
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http://linked.open...i/cep/druhSouteze
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http://linked.open...ep/duvernostUdaju
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http://linked.open.../cep/fazeProjektu
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http://linked.open...ai/cep/hlavniObor
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http://linked.open...hodnoceniProjektu
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http://linked.open...vai/cep/kategorie
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http://linked.open.../cep/klicovaSlova
| - konfigurace, stereochemie, NMR v roztoku a v pevné fázi, sulfoxidy, N-oxidy, fosfinoxidy, fosfonáty, (en)
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http://linked.open...ep/partnetrHlavni
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http://linked.open...inujicichPrijemcu
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http://linked.open...cep/pocetPrijemcu
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http://linked.open...ocetSpoluPrijemcu
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http://linked.open.../pocetVysledkuRIV
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http://linked.open...enychVysledkuVRIV
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http://linked.open...lneniVMinulemRoce
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http://linked.open.../prideleniPodpory
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http://linked.open...iciPoslednihoRoku
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http://linked.open...atUdajeProjZameru
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http://linked.open.../vavai/cep/soutez
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http://linked.open...usZobrazovaneFaze
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http://linked.open...ai/cep/typPojektu
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http://linked.open...ep/ukonceniReseni
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http://linked.open.../cep/vedlejsiObor
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http://linked.open...ep/zahajeniReseni
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http://linked.open...jektu+dodavatelem
| - Řešení projektu proběhlo výtečně, jak z hlediska odborného tak i z hlediska čerpání finančních prostředků. (cs)
- The project was excellent, both in terms of expertise and in terms of disbursement of funds. (en)
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http://linked.open...tniCyklusProjektu
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http://linked.open.../cep/klicoveSlovo
| - N-oxidy
- NMR v roztoku a v pevné fázi
- fosfinoxidy
- fosfonáty
- stereochemie
- sulfoxidy
- konfigurace
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is http://linked.open...vavai/riv/projekt
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is http://linked.open...vavai/cep/projekt
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