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| rdfs:seeAlso
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| Description
| - Polyazacyclesless and/or unsymetrically substituted with phosphorus acid pendant arms willbe synthesized and their coordination ability toward di-/tri-valent metal ionswill be investigated. Complexes of the ligands should retain convenientproperties of such complexes of analogous carboxylic ligands (thermodynamic/kinetic stability) butshould provide some improved physico-chemical properties as complexation rates.Thermodynamic, kinetic and spectroscopic properties of these compounds will beinvestigated under chemical conditions. Selected ligands/complexes will beinvestigated under radiochemical conditions (complexation, stability).Compounds with desired properties (suitable for use in nuclear medicine fordiagnosis/therapy) will be investigated in vitro or in vivo and conjugated tobiological vectors. The main aim of the Project is an understanding how aligand structure (size of macrocycle, number and/or kind of pendant arms,placement of the pendant arms) influences properties of the complexes formedand how the properties are altered on a way from the low-molecular-weightcomplexes to larger organized systems. An import part consists from a developmentof technology for use of suitable isotopes and complexes as newradiopharmaceuticals. (en)
- Cílem je lepší porozumění zákonitostem, jak struktura ligandu (velikost kruhu; počet, typ nebo umístění pendantů) ovlivňuje vlastnosti jejich komplexů, které jsou podstatné pro jejich možné využití v nukleární medicíně; příprava technologie pro možná radiofarmaka založená na těchto ligandech.
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| Title
| - Macrocyclic ligands suitable for development of new radiopharmaceuticals based on metal isotopes (en)
- Makrocyklické ligandy vhodné pro vývoj nových radiofarmak založených na izotopech kovů
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| skos:notation
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| http://linked.open...avai/cep/aktivita
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| http://linked.open...kovaStatniPodpora
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| http://linked.open...ep/celkoveNaklady
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| http://linked.open...datumDodatniDoRIV
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| http://linked.open...i/cep/druhSouteze
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| http://linked.open...ep/duvernostUdaju
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| http://linked.open.../cep/fazeProjektu
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| http://linked.open...ai/cep/hlavniObor
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| http://linked.open...hodnoceniProjektu
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| http://linked.open...vai/cep/kategorie
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| http://linked.open.../cep/klicovaSlova
| - makrocykly; radionuklidy kov; terodynamická a kinetická stabilita; radiofarmaka (en)
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| http://linked.open...ep/partnetrHlavni
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| http://linked.open...inujicichPrijemcu
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| http://linked.open...cep/pocetPrijemcu
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| http://linked.open...ocetSpoluPrijemcu
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| http://linked.open.../pocetVysledkuRIV
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| http://linked.open...enychVysledkuVRIV
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| http://linked.open...lneniVMinulemRoce
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| http://linked.open.../prideleniPodpory
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| http://linked.open...iciPoslednihoRoku
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| http://linked.open...atUdajeProjZameru
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| http://linked.open.../vavai/cep/soutez
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| http://linked.open...usZobrazovaneFaze
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| http://linked.open...ai/cep/typPojektu
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| http://linked.open...ep/ukonceniReseni
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| http://linked.open.../cep/vedlejsiObor
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| http://linked.open...ep/zahajeniReseni
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| http://linked.open...jektu+dodavatelem
| - Řešení projektu proběhlo výtečně, jak z hlediska odborného tak i z hlediska čerpání finančních prostředků. (cs)
- The project was excellent, both in terms of expertise and in terms of disbursement of funds. (en)
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| http://linked.open...tniCyklusProjektu
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| http://linked.open.../cep/klicoveSlovo
| - radionuklidy kov
- terodynamická a kinetická stabilita
- makrocykly
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| is http://linked.open...vavai/riv/projekt
of | - Gd(III) complex of a monophosphinate-bis(phosphonate) DOTA analogue with a high relaxivity; Lanthanide(III) complexes for imaging and radiotherapy of calcified tissues
- Chemical, radiochemical and biological studies of Sm and Ho complexes of H4dota analogues containing one methylphosphonic/ phosphinic acid pendant arm
- Towards MRI contrast agents responsive to Ca(II) and Mg(II) ions: Metal-induced oligomerization of dota-bisphosphonate conjugates
- A Triazacyclononane-Based Bifunctional Phosphinate Ligand for the Preparation of Multimeric 68Ga Tracers for Positron Emission Tomography
- Lanthanide(III) Complexes of 4,10-Bis(phosphonomethyl)-1,4,7,10- tetraazacyclododecane-1,7-diacetic acid (trans-H6do2a2p) in Solution and in the Solid State: Structural Studies Along the Series
- Gallium(III) Complexes of DOTA and DOTA-Monoamide: Kinetic and Thermodynamic Studies
- TRAP, a Powerful and Versatile Framework for Gallium-68 Radiopharmaceuticals
- A New Tris(phosphonomethyl) Monoacetic Acid Cyclam Derivative: Synthesis, Acid-Base and Metal Complexation Studies
- Complexation of Metal Ions with TRAP (1,4,7-Triazacyclononane Phosphinic Acid) Ligands and 1,4,7-Triazacyclononane-1,4,7-triacetic Acid: Phosphinate-Containing Ligands as Unique Chelators for Trivalent Gallium
- Mn(2+) complexes of 1-oxa-4,7-diazacyclononane based ligands with acetic, phosphonic and phosphinic acid pendant arms: Stability and relaxation studies
- Radiolabeling of PAMAM dendrimers conjugated to a pyridine-N-oxide DOTA analog with (111)In: Optimization of reaction conditions and biodistribution
- Metal Complexes of 4,11-Dimethyl-1,4,8,11-tetraazacyclotetradecane-1,8-bis(methylphosphonic acid) – Thermodynamic and Formation/Decomplexation Kinetic Studies
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| is http://linked.open...vavai/cep/projekt
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