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| Description
| - Studies of cell differentiation, spatial position, cell-cell interaction and signaling within organized yeast communities such as colonies and biofilms have revealed the existence of unique processes associated with the yeast multicellular life-style. These findings showed that specific attributes attributed previously only to metazoans have their counterparts in yeast multicellular structures. Yeast colonies therefore recently became an excellent simple model for investigation of these processes, the molecular principles of which are often conserved among eukaryotes, including humans. Recent findings of both Czech teams behind this proposal showed that colonies behave as simple multicellular organisms in which cells differentiate, acquire specific properties and communicate with each other. The main aim of the project is to identify, using next-generation DNA/RNA sequencing methodology provided by the Norwegian partner, novel molecular mechanisms involved in development of yeast cells within differentiated colony resembling cells of mammalian solid tumors, as well as those involved in development of protective mechanisms in yeast biofilm colonies. The research is based on recent findings of both Czech partners regarding metabolic parallels between differentiated yeast colonies and tumor-affected organism and of those regarding defense strategies in biofilm colonies. YEASTSEQ will also create new long-term cooperation between Czech and Norwegian teams and significantly expand the knowledge and skills of the participating teams, including PhD students and young researchers. Specific aims include: i) Quantitative analysis of transcriptomes of different types of differentiated cells of yeast colonies by RNA Seq; ii) identification of the mutation rate in the cell subpopulations by whole genome re-sequencing and iii) determining of epigenetic regulations involved in the reprogramming of structured biofilm colonies by FAIRE and Chromatin Immunoprecipitation (ChIP).
- Studies of cell differentiation, spatial position, cell-cell interaction and signaling within organized yeast communities such as colonies and biofilms have revealed the existence of unique processes associated with the yeast multicellular life-style. These findings showed that specific attributes attributed previously only to metazoans have their counterparts in yeast multicellular structures. Yeast colonies therefore recently became an excellent simple model for investigation of these processes, the molecular principles of which are often conserved among eukaryotes, including humans. Recent findings of both Czech teams behind this proposal showed that colonies behave as simple multicellular organisms in which cells differentiate, acquire specific properties and communicate with each other. The main aim of the project is to identify, using next-generation DNA/RNA sequencing methodology provided by the Norwegian partner, novel molecular mechanisms involved in development of yeast cells within differentiated colony resembling cells of mammalian solid tumors, as well as those involved in development of protective mechanisms in yeast biofilm colonies. The research is based on recent findings of both Czech partners regarding metabolic parallels between differentiated yeast colonies and tumor-affected organism and of those regarding defense strategies in biofilm colonies. YEASTSEQ will also create new long-term cooperation between Czech and Norwegian teams and significantly expand the knowledge and skills of the participating teams, including PhD students and young researchers. Specific aims include: i) Quantitative analysis of transcriptomes of different types of differentiated cells of yeast colonies by RNA Seq; ii) identification of the mutation rate in the cell subpopulations by whole genome re-sequencing and iii) determining of epigenetic regulations involved in the reprogramming of structured biofilm colonies by FAIRE and Chromatin Immunoprecipitation (ChIP). (en)
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| Title
| - 3D yeast colony genomics: A model for cancer progression and development of drug resistance in biofilms
- 3D yeast colony genomics: A model for cancer progression and development of drug resistance in biofilms (en)
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| skos:notation
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| http://linked.open...avai/cep/aktivita
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| http://linked.open...kovaStatniPodpora
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| http://linked.open...ep/celkoveNaklady
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| http://linked.open...datumDodatniDoRIV
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| http://linked.open...i/cep/druhSouteze
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| http://linked.open...ep/duvernostUdaju
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| http://linked.open.../cep/fazeProjektu
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| http://linked.open...ai/cep/hlavniObor
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| http://linked.open...vai/cep/kategorie
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| http://linked.open.../cep/klicovaSlova
| - Cell signaling and cellular interactions, cell differentiation and physiology, microbiology, yeast colonies, model of organisms affected by a cancer, development and ageing, genomics of yeast cell subpopulations, resistance of biofilm colonies, extracel… (en)
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| http://linked.open...ep/partnetrHlavni
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| http://linked.open...inujicichPrijemcu
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| http://linked.open...cep/pocetPrijemcu
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| http://linked.open...ocetSpoluPrijemcu
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| http://linked.open.../pocetVysledkuRIV
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| http://linked.open...enychVysledkuVRIV
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| http://linked.open...lneniVMinulemRoce
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| http://linked.open.../prideleniPodpory
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| http://linked.open...iciPoslednihoRoku
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| http://linked.open...atUdajeProjZameru
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| http://linked.open.../vavai/cep/soutez
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| http://linked.open...usZobrazovaneFaze
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| http://linked.open...ai/cep/typPojektu
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| http://linked.open...ep/ukonceniReseni
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| http://linked.open.../cep/vedlejsiObor
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| http://linked.open...ep/zahajeniReseni
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| http://linked.open...tniCyklusProjektu
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| http://linked.open.../cep/klicoveSlovo
| - microbiology
- cell differentiation and physiology
- development and ageing
- genomics of yeast cell subpopulations
- model of organisms affected by a cancer
- resistance of biofilm colonies
- yeast colonies
- Cell signaling and cellular interactions
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| is http://linked.open...vavai/cep/projekt
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