About: Structural and functional analysis of interaction between calmodulin and plectin isoform 1a

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Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/domain/vavai/Projekt
rdfs:seeAlso	http://www.isvav.cz/projectDetail.do?rowId=7AMB13AT012
Description	The major objective of this project is to decipher the structural basis of the interaction between the calmodulin and the N-terminal actin binding domain of plectin isoform 1a and to provide the model with a functional-structural basis. Following goals will be pursued: i) To investigate interaction of calmodulin with the N-terminal domain of plectin isoform 1a (1aABD) - structural analysis of the interaction between calmodulin and N-terminal domain of plectin isoform 1a ii) To study the mechanism of calmodulin-dependent disruption of the interaction between plectin and integrin - analysis of the disassembly mechanism of intergrin-plectin complex after binding of calmodulin iii) To address the role of calmodulin in modulation of the function of actin binding domains - analysis and comparison of ABDs from a selected number of actin binding proteins, which calmodulin and CaM-like domain bind. iv) To test and validate proposed model of calmodulin-plectin 1a interaction ex vivo - structural analysis of the interaction between calmodulin and N-terminal domain of plectin isoform 1a and analysis of the disassembly mechanism of intergrin-plectin complex after binding of calmodulin ex vivo. (en) The major objective of this project is to decipher the structural basis of the interaction between the calmodulin and the N-terminal actin binding domain of plectin isoform 1a and to provide the model with a functional-structural basis. Following goals will be pursued: i) To investigate interaction of calmodulin with the N-terminal domain of plectin isoform 1a (1aABD) - structural analysis of the interaction between calmodulin and N-terminal domain of plectin isoform 1a ii) To study the mechanism of calmodulin-dependent disruption of the interaction between plectin and integrin - analysis of the disassembly mechanism of intergrin-plectin complex after binding of calmodulin iii) To address the role of calmodulin in modulation of the function of actin binding domains - analysis and comparison of ABDs from a selected number of actin binding proteins, which calmodulin and CaM-like domain bind. iv) To test and validate proposed model of calmodulin-plectin 1a interaction ex vivo - structural analysis of the interaction between calmodulin and N-terminal domain of plectin isoform 1a and analysis of the disassembly mechanism of intergrin-plectin complex after binding of calmodulin ex vivo.
Title	Structural and functional analysis of interaction between calmodulin and plectin isoform 1a (en) Strukturně- funkční analýza interakce mezi kalmodulinem a plektinem 1a
skos:notation	7AMB13AT012
http://linked.open...avai/cep/aktivita	The sixth framework programme of the European Community for research, technological development and demonstration activities
http://linked.open...kovaStatniPodpora	http://linked.opendata.cz/resource/domain/vavai/projekt/7AMB13AT012/celkovaStatniPodpora
http://linked.open...ep/celkoveNaklady	http://linked.opendata.cz/resource/domain/vavai/projekt/7AMB13AT012/celkoveNaklady
http://linked.open...datumDodatniDoRIV	2014-06-12 (xsd:date)
http://linked.open...i/cep/druhSouteze	RP - Spolufinancování programu ES
http://linked.open...ep/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open.../cep/fazeProjektu	100399989
http://linked.open...ai/cep/hlavniObor	EB - Genetika a molekulární biologie
http://linked.open...vai/cep/kategorie	ZV - Základní výzkum
http://linked.open.../cep/klicovaSlova	plectin; calmodulin (en)
http://linked.open...ep/partnetrHlavni	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...inujicichPrijemcu	0 (xsd:int)
http://linked.open...cep/pocetPrijemcu	1 (xsd:int)
http://linked.open...ocetSpoluPrijemcu	0 (xsd:int)
http://linked.open.../pocetVysledkuRIV	0 (xsd:int)
http://linked.open...enychVysledkuVRIV	0 (xsd:int)
http://linked.open...lneniVMinulemRoce	2013-03-22 (xsd:date)
http://linked.open.../prideleniPodpory	http://linked.opendata.cz/resource/domain/vavai/cep/prideleniPodpory/MSMT-5278%2F2013-311
http://linked.open...iciPoslednihoRoku	2014
http://linked.open...atUdajeProjZameru	2014
http://linked.open...usZobrazovaneFaze	DRRVK
http://linked.open...ai/cep/typPojektu	P - Projekt výzkumu a vývoje financovaný ze státního rozpočtu
http://linked.open...ep/ukonceniReseni	2014-12-31 (xsd:date)
http://linked.open...ep/zahajeniReseni	2013-01-01 (xsd:date)
http://linked.open...tniCyklusProjektu	ZK
http://linked.open...n/vavai/cep/vyzva	http://linked.opendata.cz/resource/domain/vavai/cep/vyzva/FP6-2004-Mobility-12
http://linked.open.../cep/klicoveSlovo	plectin
is http://linked.open...vavai/cep/projekt of	http://linked.opendata.cz/resource/domain/vavai/cep/ucast/7AMB13AT012/2013/ico%3A68378050 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/7AMB13AT012/2014/ico%3A68378050

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