About: Identification of Cyclooxygenase and Lipoxygenase Inhibitors from Vine Grapes     Goto   Sponge   NotDistinct   Permalink

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Description
  • The aim is to elucidate, if - besides resveratrol - there are some other compounds contained in wine which are able to inhibit the activity of COX-1, COX-2 and 5-LOX enzymes. The inhibitory activity of studied compounds will be assessed in vitro on the mentioned enzymes (will be done by the Czech group) and the binding mechanism of the active compounds in the enzyme binding site will be studied in silico by the molecular modeling group in Austria. The main aim of this project is a functional collaboration between the Czech and Austrian groups to study the inhibition of the arachidonic acid pathway by compounds from red wines and their metabolites. (en)
  • Cílem je zjistit, zda se ve víně vyskytují aktivní inhibitory (jiné než resveratrol) pro-zánětlivých enzymů COX-1 (cyklooxygenáza-1), COX-2 (cyklooxygenáza-2) a 5-LOX (5-lipoxygenáza). U aktivních látek bude stanovena inhibiční aktivita u zmíněných enzymů (bude probíhat na českém pracovišti) a bude provedeno zjištění interakcí ve vazebném místě enzymu pomocí počítačového modelování (bude probíhat na rakouském pracovišti). Hlavním cílem projektu je fungující spolupráce mezi českým a rakouským týmem. To znamená probíhající výměny pracovníků a dovedností.
Title
  • Identification of Cyclooxygenase and Lipoxygenase Inhibitors from Vine Grapes (en)
  • Identifikace inhibitorů cyklooxygenáz a lipoxygenáz obsažených v révě vinné
skos:notation
  • 7AMB13AT008
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  • cyclooxygenase, lipoxygenase, anti-inlammatory activity, vine grapes, wine, Vitis vinifera (en)
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  • cyclooxygenase
  • wine
  • anti-inlammatory activity
  • lipoxygenase
  • vine grapes
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