About: Mutations of ryanodine receptor in relationship to malignant arrhythmias and sudden cardiac death in patients with heart failure     Goto   Sponge   NotDistinct   Permalink

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Description
  • The aim of the project is to contribute to better understanding of sudden cardiac death pathophysiology. The study population will consist of high risk patients with heart failure who survived malignant ventricular arrhythmia. In these individuals occurence of RyR2 gene polymorphisms will be investigated compared to a control group to assess the role of RyR2 in arrhythmogenesis. Working hypothesis is based on fact that in catecholaminergic polymorphic ventricular tachycardia a significant number of asymptomatic RyR2 mutation carriers have been found. Such a latent mutation will reveal only under stress conditions - in heart failure - and it will contribute to malignant arrhythmia and sudden death. (en)
  • Cílem projektu je zjistit výskyt polymorfizmů genu RyR2 u vysoce rizikové skupiny pacientů s chronickým srdečním selháním, kteří přežili nahromadění maligních komorových arytmií – tzv. arytmickou bouři - tedy přežili NSS
Title
  • Mutations of ryanodine receptor in relationship to malignant arrhythmias and sudden cardiac death in patients with heart failure (en)
  • Mutace ryanodinového receptoru ve vztahu k maligním arytmiím a náhlé srdeční smrti u pacientů se srdečním selháním
skos:notation
  • 2B08061
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  • arrhythmia; gene; heart failure; ion channel; mutation; ryanodine receptor; RyR2; sudden death (en)
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  • The research was realized according to the schedule. The expected results have been probably achieved (en)
  • Řešení probíhalo podle plánu. Očekávaných výsledků bylo pravděpodobně dosaženo. (cs)
http://linked.open...tniCyklusProjektu
http://linked.open.../cep/klicoveSlovo
  • arrhythmia
  • gene
  • ion channel
  • mutation
  • RyR2
  • heart failure
  • ryanodine receptor
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