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Description
  • Identification of human cytochrome P450 isozymes involved in the metabolism of memantine and amiodarone. Quantification of inhibitory action of memantine towards human cytochorome P450 isozymes. (en)
  • Identifikace izoenzymů cztochromu P450, které se účastní biotransformace memantinu a amiodaronu u člověka. Kvantifikace inhibičního působení memantinu na lidské izoenzymy cytochromu P450 u člověka. Předpovědět lékové interakce memantinu.
Title
  • Prediction of metabolic drug-drug interactions based on in-vitro experiments (en)
  • Predikce metabolických lékových interakcí s využitím in-vitro metodik
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  • 1P04OCB15.30
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  • cytochrome P450, memantine, amiodarone, drug-drug interaction, (en)
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  • Vypracování in vitro metod umožňujících in vivo predikci farmakokinetických vlastností nových léků (cs)
  • Development of in vitro methods enabling in vivo prediction of pharmacokynetic features od new medicaments (en)
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  • cytochrome P450
  • amiodarone
  • drug-drug interaction
  • memantine
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