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  • Předmětem řešení předloženého projektu je objasnění významu nekanonické Wnt dráhy pro diagnózu, určení prognózy a pro molekulární patogenezi chronické lymfocytární leukémie (CLL). Cíle bude dosaženo detailní analýzou exprese komponent nekanonické Wnt dráhy na úrovni RNA (kvantitativní RT-PCR) a proteinů (Western Blotting a flowcytometrie) u klinicky dobře definových pacientů s CLL. Dále budou analyzovány in vitro základní parametry (apoptóza a migrace) B-lymfocytů z pacientů a to, jak jsou tyto parametry modulovány cílenými změnami v expresi součástí nekanonické Wnt dráhy. (cs)
  • The proposed project attempts to clarify the role of non-canonical Wnt pathway in diagnosis, prognosis and in molecular pathogenesis of chronic lymphocytic leukemia (CLL). The proposed goal will be achieved by expression analysis of the components of non-canonical Wnt pathway at transcript (RT-PCR) and protein level (Western blotting and flow-cytometry) in clinically well defined CLL patients. Furthermore, we will analyze basic parameters (apoptosis, migration) of patient B-cells and how are these parameters modulated by directed modulation of non-canonical Wnt signaling. (en)
Title
  • The role of non-canonical Wnt signaling in molecular pathogenesis of chronic lymphocytic leukemia (en)
  • Úloha nekanonické Wnt signalizace v molekulární patogenezi chronické lymfocytární leukémie (cs)
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  • chronic lymphocytic leukemia; non-canonical Wnt signaling; lymphocyte migration; prognostic and diagnostic mark (en)
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