About: The role of B cell lineage mitotic disruptions in multiple myeloma     Goto   Sponge   NotDistinct   Permalink

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  • 1. Centrosome amplification presents in malignant plasma cells and probably in their precursors in multiple myeloma. 2. This project is aimed on gene analysis (Array-CGH) with detailed expression analysis of chosen structural and functional genes, involved in mitotic disruption in clonal cells in MM (RT-PCR). 3. It aims to find by RT-PCR and IF staining new prognostic markers which will be important for diagnosis, classification and prediction of MM development. (en)
  • 1. Centrozomové amplifikace se nachází v maligních plazmatických buňkách a pravděpodobně i v prekurzorech v MM. 2. Tento projekt se věnuje genové analýze (Array-CGH) s detailní expresní analýzou vybraných strukturálních a funkčních genů, které se účastní mitotické disrupce klonálních buněk v MM (RT-PCR). 3. Tento projekt použije RT-PCR a IF barvení pro nalezení nových prognostických markerů, které budou důležité pro diagnózu, klasifikaci a predikci MM. (cs)
Title
  • The role of B cell lineage mitotic disruptions in multiple myeloma (en)
  • Úloha mitotické disrupce v B lymfocytech u mnohočetném myelomu (cs)
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  • centrosome amplification; mitotic disruption; multiple myeloma; B-lineage cells; arrayCGH; real-time PCR; prognostic significance (en)
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