About: Mechanisms involved in epigenetic control of expression and function of androgen receptor (AR) in prostate cancer: Potential therapeutic implications of AR coactivators blockade.     Goto   Sponge   NotDistinct   Permalink

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  • 1/ Regulation of mechanism by which corepressors compete with coactivators for binding to androgen receptor. 2/ Elucidate an effect of the inhibitor histone deacetylation on changes of covalent histone modifications. 3/ Determine whether histone modifications changes (acetylation and methylation) stimulate corepressors or they are results of their activation. 4/ If we suppose that methylation could be a reason of androgen receptor silencing, we would like to test the effect of demethylation agents or a its combination with inhibitor of histone deacetylation, on possible expression of androgen receptor. (en)
  • 1/ Regulace mechanismu, při kterém se korepresory společně s koaktivátory ucházejí o vazbu s androgenovým receptorem. 2/ Objasnit vliv inhibitoru histonových deacetylaz na změny kovalentních histonových modifikací. 3/ Zjistit, zda-li změny histonových modifikací (acetylace a metylace) stimulují korepresory anebo jsou důsledkem jejich aktivace. 4/ Předpokládáme-li, že metylace může být příčinou umlčení exprese androgenového receptoru, ověřit účinek demetylačního agens případně v jeho kombinaci s inhibitorem histonových deacetyláz na obnovenou expresi androgenového receptoru. (cs)
Title
  • Mechanismy epigenetické kontroly exprese a funkce androgenového receptoru (AR) u karcinomu prostaty: Možné terapeutické implikace blokády koaktivátorů AR (cs)
  • Mechanisms involved in epigenetic control of expression and function of androgen receptor (AR) in prostate cancer: Potential therapeutic implications of AR coactivators blockade. (en)
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  • androgen receptor; acetylation; deacetylation; inhibitor histone deacetylatio; methylation; korepressor, prostate cancer (en)
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