About: Genetic profile of biotransformation and DNA repair genes in cancer patients from the Czech Republic.

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About: Genetic profile of biotransformation and DNA repair genes in cancer patients from the Czech Republic. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Projekt, within Data Space : linked.opendata.cz associated with source document(s)

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Description	Evaluation of links between individual genetic background - evaluation of polymorphisms in both DNA repair and XME genes and expression levels in lymphocytes in cancer patients and healthy controls in Czech Republic. Determination of expression profiles of DNA repair and XME genes in comparison with genetic profiles and outcomes from the functional tests. A study on genotype-phenotype relations with special regard to prognosis and therapy outcome. (en) Hodnocení polymorfismů a jejich vzájemných vztahů u genů DNA reparace a u genů účastnících se biotransformace u pacientů s nádorovým onemocněním a u zdravých kontrol v české populaci. Porovnání profilů expresí XME a DNA reparačních genů s genetickými profily a konfrontace s výsledky funkčních testů. Zavedení metod pro stanovení jednonukleotidového polymorfismu (SNP) v různých DNA reparačních genech (XPA, hOGG1, APE1 a NBS1). DNA bude izolována z leukocytů a XME i DNA reparační genetické polymorfismy budou stanovovány metodou PCR-RFLP. (cs)
Title	Genetický profil genů metabolismu xenobiotik a DNA reparace u pacientů s novotvary a u kontrolních osob v České republice. (cs) Genetic profile of biotransformation and DNA repair genes in cancer patients from the Czech Republic. (en)
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http://linked.open...vai/klicova-slova	carcinogenesis; genetic polymorphismus; metabolizing enzymes genes; repair DNA enzymes genes; oncological diseases; gene expression; gen repair and functional test (en)
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