About: Molecular and functional cancer-associated perturbances in JAK/STAT/SOCS proteins and in their target genes expression     Goto   Sponge   NotDistinct   Permalink

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  • Studie hodlá analyzovat molekulární a funkční abnormality v signálních proteinech STAT/SOCS a v expresi jejich cílových genů, které jsou specifické pro nádorová onemocnění, a mohly by představovat nové nádorové markery a být nápomocné při imunoterapii. Výsledky by mohly rozšířit naše znalosti o tom, jak výše zmíněné systémy fungují a interagují v přenosu signálu interferonů a jaké jsou důsledky defektní aktivity v signálních mediátorech. Western a Northern hybridizace, technika tkáňových kultur a DNA makroarray expresní profily zastupují dominantní metody. (cs)
  • The study intends to analyze molecular and functional cancer-specific abnormalities in STAT/SOCS signaling proteins and in the expression of their target genes which might represent new tumor markers and be of help in immunotherapeutic strategies. The results are also expected to extend our understanding how the above signaling systems operate and interact in interferon-induced signaling and what are the consequences of defective activity within signaling mediators. Western and Northern hybridization, tissue cultures and DNA macroarray expression profiling exemplify the dominant methods. (en)
Title
  • Molecular and functional cancer-associated perturbances in JAK/STAT/SOCS proteins and in their target genes expression (en)
  • Charakterizace molekulárních a funkčních poruch v proteinech JAK/STAT/SOCS a v expresi jejich cílových genů v nádorové buňce (cs)
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  • STAT; SOCS; interferons; malignant melanoma; signal transduction; DNA macroarrays (en)
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