About: -Oxygenated steroids as immunomodulators and thermogenic factors     Goto   Sponge   NotDistinct   Permalink

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  • Hladiny 7-hydroxylovaných metabolitů DHEA budou sledovány u souborů nemocných s autoimunitními endokrinopatiemi a u nemocných léčených glukokortikoidy. Vyšetření 7-OH-DHEA by tak sloužilo jako nezávislý ukazatel rozvoje autoimunitních pochodů. Hladiny 7-oxo-DHEA, považovaného za termogenní faktor, budou vyšetřeny u souborů nemocných s poruchami termogeneze - u tyreopatií a u obézních. Pro tyto účely bude vyvinuta originální metoda a zmapovány hladiny tohoto steroidu v populaci. (cs)
  • The levels of 7-hydroxylated DHEA metabolites will be followed up in patients with autoimmune endocrinopathies and in those treated with glucocorticoids. Investigation of 7-OH-DHEA should thus serve as an independent marker of autoimmune processes. 7-Oxo-DHEA, known to act as thermogenic factor, will be investigated in patients with impaired thermogenesis as in thyreopathies and in obese subjects. A method for determination of 7-oxo-DHEA will be developed and used for its mapping in population. (en)
Title
  • 7-Oxygenované steroidy jako imunomodulátory a termogenní faktory (cs)
  • -Oxygenated steroids as immunomodulators and thermogenic factors (en)
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  • DHEA; 7-OH-DHEA; 7-oxo-DHEA; autoimmunity; thyreopathies; thermogenesis; obesity; antiglucocorticoids (en)
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