About: Tumours of human papillomavirus origin with different expression of MHC class I molecules: theoretical principles of immunotherapy.     Goto   Sponge   NotDistinct   Permalink

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  • V rámci grantového projektu bude potvrzeno nebo vyvráceno, že není imunologická zkřížená reaktivita mezi MHC I positivními MHC I negativníni nádory stejné etiologie. Bude zjištěno, jaká je nadprahová úroveň exprese MHC I, aby byla nádorová buňka rozpoznána specifickými cytotoxickými lymfocyty. Bude studováno, jakou roli hrají pomocné lymfocyty v imunitní odpovědí proti MHC I positivním a negativním nádorům. (cs)
  • In this grant project it will be investigated whether there is a lack of immunological cross-reactivity between MHC class I positive and MHC class I negative tumours. It will be determined whether cytotoxic T lymphocytes recognise as targets tumour cells expressing supra-treshold levels of the MHC class I molecules. It will be investigated whether T helper cells play a role in the immune response against both MHC class I positive and negative tumours. (en)
Title
  • Nádory asociované s lidskými papilomaviry s rozdílnou expresí MHC I molekul; teoretické principy imunoterapie. (cs)
  • Tumours of human papillomavirus origin with different expression of MHC class I molecules: theoretical principles of immunotherapy. (en)
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  • tumours; MHC class I; immunotherapy; HPV-16 (en)
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