About: Intermittent androgen blockade abd androgen receptor mutation     Goto   Sponge   NotDistinct   Permalink

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  • Zjištění, zda intermitentní androgenní blokáda selektuje mutace androgenního recepotoru, a proč je znovunabytí androgenní senzitivity pouze dočasné. Zjištění, zda je progrese do hormonrezistentního stádia spojena s mutacemi androgenních receptorů. Stanovení změn androgenních receptorů během cyklů intermitentní blokády. Stanovení ovlivnění viability buněk s mutovaným androgenním receptorem v nádorové populaci. (cs)
  • Mechanism why intermittent androgen blockade selects androgen receptor mutations and why regaing sensitivity to therapy is only temporary will be researched. Whether androgen receptor mutations are responsible for progression to hormonally escaped tumour will be examined. Changes of androgen receptors during intermittent blockade cycles will be described. Viability of cells with androgen receptor mutations in tumour population will be ionvestigated. (en)
Title
  • Intermittent androgen blockade abd androgen receptor mutation (en)
  • Intermitentní androgenní blokáda a mutace androgenního receptoru (cs)
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  • prostate cancer;biopsy;androgen receptor;intermittent androgen therapy;AR mutation (en)
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