About: Preparation and redioactive labelling of low-molecular weigth proteins and peptides with tissue-specific distribution     Goto   Sponge   NotDistinct   Permalink

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  • Low-molecular weight proteins and poptides produced by degradation of high-molecular weight substances after isolation using chromatographic methods and protein-membrane separation are labelled with the radionuclides 99mTc and 186Re using redox polymers.High radiochemocal purity and stability of the labelled producst and their spacifuc biodistribution into pathologically altered tissues are expected. These substances may play a role as radiopharmaceuticals for the diagnosis and treatment in casea where there are no suitable radioactive drugs available at the momet. (en)
  • Nízkomolekulární proteiny a peptidy získané štěpením vysokomolekulárních látek se po izolaci pomocí chromatografických metod a proteinové membránové separace značí radionuklidy techneciem (99mTc) a rheniem (18 6Re) za použití redox polymerů. Předpokládá se vysoká radiochemická čistota a stabilita značených produktů a jejich cílená bidistribuce do patologicky změněných tkání. Tyto látky se mohou ulatnit jako radiofarmaka pro diagnostiku nebo i terapii v případech, kde nejsou v současné době k dispozici vhodná radioaktivní léčiva. (cs)
Title
  • Preparation and redioactive labelling of low-molecular weigth proteins and peptides with tissue-specific distribution (en)
  • Příprava a radioaktivní značení nízkomolekulárních proteinů a peptidů s tkáňově specifickou distribucí (cs)
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  • Radionuclides;Proteins;Peptides;Technetium(99mTc);Rhenium (186 Re);Redox polymers;Radioanalysis;Biodistribution (en)
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