About: Interaction of nitric oxide, peroxynitrite and oxidative stress in clinically relevant model of septic shock in pig

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About: Interaction of nitric oxide, peroxynitrite and oxidative stress in clinically relevant model of septic shock in pig Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Projekt, within Data Space : linked.opendata.cz associated with source document(s)

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Description	Řešení úlohy selektivní inhibice iNOS v kombinaci s neutralizací superoxidu s cílem zabránit toxickému vlivu NO a jeho derivátu peroxynitritu u septického šoku. Charakterizovat význam interakce oxid dusnatý-peroxynitrit v patofyziologii sepsí indukovaných změn v hepato-splanchnické oblasti. Projekt je realizován na experimentálním klinicky relevantním, endotoxinem indukovaném, hyperdynamickém modelu septického šoku prasete, který úzce imituje patofyziologii septického šoku v klinické situaci. (cs) To investigate the role of selective iNOS inhibition together with superoxide scavenging aimed at limiting NO-mediated cell/organ injury in septic shock. To investigate the role of nitric oxide -peroxynitrite interplay in the pathophysiology of sepsis-induced derangements in the hepato-splanchnic region. The objectives of the project will be studied in a longterm, hyperdynamic and hypermetabolic porcine model of septic shock mimicking human septic pathophysiology. (en)
Title	Interaction of nitric oxide, peroxynitrite and oxidative stress in clinically relevant model of septic shock in pig (en) Interakce oxidu dusnatého, peroxynitritu a oxidativního stresu u klinicky relevantního modelu septického šoku (cs)
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http://linked.open...vai/klicova-slova	nitric oxide;iNOS;peroxynitrite;oxidative stress;septic shock (en)
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is http://linked.open...ain/vavai/projekt of	http://linked.opendata.cz/resource/domain/vavai/cep/ucast/2001/ND6837/orjk-11140 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/2002/ND6837/orjk-11140 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/2003/ND6837/orjk-11140 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/2004/ND6837/orjk-11140

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