About: Diabetes mellitus and the polymorphism in the promotor gene for the monocyte CD14 receptor.     Goto   Sponge   NotDistinct   Permalink

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  • Náplní studie je zmapovat polymorfismus v promotoru pro gen monocytárního receptoru CD14 u diabetiků typu 1 a 2 a srovnat tyto skupiny s kontrolním souborem. Prokázat předpoklad, že pacienti s diabetem typu 2 mají zvýšenou monocytární a plasmatickou expresi CD14 a zjistit, zda platí tyto závislosti i u diabetiků typu 1. Cílem je sledovat genetické mechanismy, které mohou být v souvislosti s rozvojem diabetu a přispívat k progresi aterosklerózy u diabetiků. (cs)
  • The study is designed to map the polymorphism in the CD14 monocyte receptor gene promotor in Type-1 and Type-2 diabetic patients and to compare these groups with a control group. To confirm the hypothesis that Type-2 diabetic patients show increased monocyte and plasma CD14 expression (upregulation) and to establish whether the same applies to Type-1 diabetes mellitus. The aim of the study is to study the genetic mechanisms possibly related to the development of diabetes and contributing to the progression of atherosclerosis in individuals with diabetes. (en)
Title
  • Diabetes mellitus and the polymorphism in the promotor gene for the monocyte CD14 receptor. (en)
  • Diabetes mellitus a polymorfismus v promotoru genu pro monocytární CD14 receptor. (cs)
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  • Diabetes mellitus;genetics;Immune system;CD14 (en)
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