About: Study of atherogenic mechanisms during treatment with LDL-apheresis: the role of fatty acid metabolism, cholesterol synthesis and lipoperoxidation     Goto   Sponge   NotDistinct   Permalink

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  • Prospective clinical study of the mutual interactions and particular role of fundamental lipid related atherogenic mechanisms in patients with familial hypercholesterolemia treated by low density lipoprotein apheresis. Project will investigate changes and correlation of the i) plasma and cell mambrane unsaturated and saturated fatty acids, ii) lipoperoxidation processes and antioxidant consumption, iii) cholesterol biosynthetic pathway and its intermediary products. The results might improve our knowledge and thus treatment of atherosclerosis, which is the leading cause of morbidity and mortality in Czech republic. (en)
  • Prospektivní klinická studie vzájemné interakce a úlohy nejdůležitějších lipidových aterogenních mechanismů u pacientů s familiární hypercholesterolémií, léčených LDL (low density lipoprotein) aferézou. Projekt bude zkoumat změny a korelace následujících parametrů: i) nenasycené a nasycené mastné kyseliny v plasmě a buněčné membráně, ii) průběh lipoperoxidace a konsumpce antioxidantů, iii) biosyntéza cholesterolu a jeho intermediárních produktů. Získané poznatky mohou přispět k objasnění a tím i k léčbě procesu aterosklerózy, která je nejčastější příčinou morbidity a mortality v České republice. (cs)
Title
  • Studium aterogenních mechanizmů při léčbě LDL-aferézou: úloha metobolizmu mastných kyselin, syntézy cholesterolu a lipoperoxidace (cs)
  • Study of atherogenic mechanisms during treatment with LDL-apheresis: the role of fatty acid metabolism, cholesterol synthesis and lipoperoxidation (en)
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  • Atherosclerosis;Hyperlipidemia;LDL-apheresis;Cholesterol synthesis;Fatty acids;Lipoperoxidation (en)
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