About: The role of free fatty acids in the pathogenesis of insulin resistance and its complications.     Goto   Sponge   NotDistinct   Permalink

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  • U experimentálního modelu insulinové resistence, u hereditárně hypertriglyceridemických potkanů, bude sledována úloha neesterifikovaných mastných kyselin v patogenesi resistence tkání k účinku insulinu. Dále bude sledován vliv neesterifikovaných mastných kyselin na funkci a metabolismus myokardu a sekreční funkci beta buněk pankreatu. Pozornost bude věnována i možnosti nutriční a farmakologické intervence poruch asociovaných s insulinovou resistencí. (cs)
  • In an experimental model of insulin resistance, in the hereditary hypertriglyceridemic rat line, the role of long-term increased circulating level of free fatty acids on muscle resistance to insulin action, heart function and metabolism will be studied. In the same model the role long-term increased circulating level of free fatty acids on pancreatic beta-cell function will be studied. The potential for nutritional and pharmacological interventions decreasing free fatty acids release from adipose tissue will be investigated. (en)
Title
  • The role of free fatty acids in the pathogenesis of insulin resistance and its complications. (en)
  • Úloha neesterifikovaných mastných kyselin v patogenezi insulinové resistence a jejích komplikací. (cs)
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  • insulin resistance;fatty acids;hypertriglyceridemia;myocardialmetabolism;insulin secretion;ACE inhibitors (en)
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