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  • Charakterizace funkčních vlastností molekuly fibrinogenu u různých vybraných skupin hemato-okologických nemocných s hyperfibrinogenémií. Zavedení a ověření metodiky pro testování vlivu hladiny a funkce fibrinogenu na počáteční fázi tvorby fibrinu a na adhezi krevních destiček. Selekce rizikových pacientů s následnou odezvou ve změně intenzity antikoagulační terapie. Využití optických metod pracujících v reálném čase, surface plasmon resonance, atomic force microscopy a hmotnostní spektrometrie MALDI-TOF. (cs)
  • Characterization of functional properties of fibrinogen in selected groups of patients with elevated levels of fibrinogen. Introduction and verification of a method of testing the effects of the level and function of fibrinogen on the initial stages of fibrin formation and blood platelet adhesion. Selection of risk-patients with subsequent response in the anticoagulant therapy. Application of highly accurate and real time optical methods - surface plasmon resonance, atomic force microscopy, mass spectrometer MALDI-TOF (matrix assisted laser desorption ionizetion - time of flight). (en)
Title
  • Hyperfibrinogemia and acquired dysfibrinogenemia. (en)
  • Hyperfibrinogenémie a získaná dysfibrinogenémie. (cs)
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  • Fibrinogen;Fibrin;Cardiovascular;Hyperfibrinogenémia;dysfibrinogenémia;Surface plasmon;Maldi-Tof;Risk faktor (en)
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