About: Instability of the genome of bone marrow cells of patients with AML and MDS.     Goto   Sponge   NotDistinct   Permalink

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  • Zjistit nenáhodnost vstupu chromosomů do přestaveb a rekurenci zlomových míst. Identifikovat geny spolupůsobící při progresi malignity a geny v oblastech s delecemi, zejména na chromosomu 5. Definovat skupiny pacientů vhodné pro individuální léčbu. (cs)
  • The aim of our study in cooperation with COST projecBM0801 is to analyse chromosomal changes in complex karyotypes of patients with MDS and AML in detail using all molecular cytogenetic techniques which are available and to search for the new, so far non-described recurrent chromosomal changes. We wish to define the frequency and significance of these aberrations for disease progression and transformation of MDS into AML. As many rearrangements are cryptic and therefore their identification is possible by molecular-cytogenetic methods only, we will exploit modifications of FISH methods routinely used in our Center of Oncocytogenetics (FISH, I-FISH. mFISH, mBAND, CGH) and as the new approach we will start to use array CGH analyses. We will start pilot study with the specially designed chip for array CGH analyses of chromosome 5. We will also continue to search for rearrangments of MLL gene in myeloid malignancies to establish prognostic values in our cohort. We have very close co-operation with clin (en)
Title
  • Nestabilita genomu buněk kostní dřeně nemocných s MDS a AML (cs)
  • Instability of the genome of bone marrow cells of patients with AML and MDS. (en)
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  • genome instability in malignant cells chromosomal aberrations molecular cytogenetics myelodysplastic syndromes (MDS) acute myeloid leukemia (AML) (en)
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