About: Ribosome biogenesis in apoptosis and aging     Goto   Sponge   NotDistinct   Permalink

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  • Cílem projektu je výzkum vlivu biogenese ribosomů na buněčné stárnutí a apoptosu. Na modelovém systému kvasinky Saccharomyces cerevisiae budeme sledovat efekt různé míry exprese vybraných regulátorů biogenese ribosomů na tyto procesy. Zvláštní důraz bude kladen na analýzu cytoplasmatického faktoru Sdo1, kvasinkového homologu lidského genu Shwachman-Bodian-Diamondova syndromu (SBDS), jehož mutace způsobuje abnormality na kostře a defekty v kostní dřeni. Věříme, že bude možné interpretovat tyto výsledky v aplikovaném lékařském výzkumu. (cs)
  • The study of apoptosis and ribosome associated cellular aging will be used in this research proposal to investigate the effect of ribosome biogenesis on these processes. We will investigate in the eukaryotic model system Saccharomyces cerevisiae the effect of gene dosage variation of selected regulators of ribosome biogenesis on apoptosis and aging. Of particular interest will be the analysis of the cytoplasmic ribosome biogenesis factor Sdo1, the yeast homolog of the human Shwachman-Bodian-Diamond syndrom (SBDS) gene, mutations of which cause abnormalities of the skeleton and bone marrow failure. We hope to be able to transfer results from basic science to medicine orientated research (en)
Title
  • Biogenese ribosomů během apoptosy a stárnutí (cs)
  • Ribosome biogenesis in apoptosis and aging (en)
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  • yeast; aging; ribosome; translation profile (en)
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