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  • The goal of this proposal is to identify novel mechanisms of interactions between neuroglial networks in the hippocampus. To test the hypothesis that the connectivity and Ca2+ signaling of astrocytic networks contribute to neuronal transmission and plasticity we set two specific aims: 1. To investigate the role of astrocytic network organization on neuronal activity and plasticity in the hippocampus. 2. To identify the astrocytic mechanisms involved in such neuronal modulation. (en)
  • Cílem projektu je identifikovat nové mechanizmy interakce mezi neuronálními a astrocytárními sítěmi v hipokampu. Abychom ověřili naši hypotézu, že propojení a Ca2+ signalizace v astrocytárních sítích přímo ovlivňuje neuronální přenos a plasticitu, stanovili jsme si dva specifické cíle: 1. Studovat vliv organizace astrocytárních sítí na neuronální aktivitu a plasticitu v hipokampu. 2. Indentifikovat astrocytární mechanizmy, zapojené do neuronální modulace. (cs)
Title
  • Role of astrocyte gap junctions in neurotransmission. (en)
  • Úloha astrocytárních gap junctions v přenosu nervového signálu. (cs)
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  • astrocytes; gap junctions; neuron-glia interaction; extrasynaptic transmission (en)
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