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  • Cílem projektu je 1. Přispět k určení složení FceRI membránových signalosomů důležitých pro degranulaci žírných buněk. 2. Přispět k určení složení membránových signalosomů důležitých pro antigenem indukovanou adhezi a chemotaxi u žírných buněk 3. Určit nové modulátory (inhibitory/aktivátory) antigenem indukované adheze, chemotaxe a degranulace u myších a lidských žírných buněk. (cs)
  • The aim of this project is: 1. To contribute to determining the composition of the FceRI membrane signalosomes important for antigen-induced degranulation in mast cells. 2. To contribute to determining the composition of membrane signalosomes important for antigen-induced adhesion and chemotaxis in mast cells. 3. To determine new modulators (inhibitors/activators) of antigen-induced degranulation, adhesion and chemotaxis in mouse and human mast cells. (en)
Title
  • Membránové signalosomy žírných buněk a bazofilů - cíle pro inovativní terapie (cs)
  • Membrane signalosomes of mast cells and basophils - targets for innovative therapies (en)
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  • mast cell; IgE receptor; immunoreceptor-induced activation; shRNA; lentiviral transduction (en)
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