This project is focused on implementation and improvement of diagnostic of clinical important beta-lactamases (ESBL, AmpC, MBL) in clinical microbiology laboratories in the Czech Republic. This programme should contribute to education of clinical microbiologists and infectious diseases specialtists and subsequently to effective tretament of infections caused by beta-lactamase-producing Gram-negative bacteria. During the project, diagnosing the diversity of clinical important beta-lactamase-producers and analyzing the relationships between beta-lactamase production and clonality. Further the epidemic characteristics of clinical important beta-lactamase-producers and the possibility of their elimination will be explored. Achieving those target goals will require characterization of beta-lactamase of strains isolated in Czech Republic region (State Health Institute), in Faculty Hospital Plzen and in Hospital Na Homolce. After that, the representation of each beta-lactamases type in invasive strains w (en)
Cílem projektu je zavedení a zlepšení diagnostiky produkce klinicky významných betalaktamáz v laboratořích klinické mikrobiologie v České republice a následně zvýšení účinnosti a efektivity léčby infekcí vyvolaných producenty těchto typů enzymů. (cs)