About: Novel treatment of genetically determined metabolic disease, type 1 diabetes, using an immunotherapeutical approach.     Goto   Sponge   NotDistinct   Permalink

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  • Cílem projektu je charakteristika genetického profilu pacientů s diabetes mellitus 1. typu a navození specifické imunitní tolerance vůči diabetogenním antigenům metodami genového inženýrství a imunologie. (cs)
  • The aim of the proposed project is a characterization of genetical profile of patients with type 1 diabetes mellitus (T1D) and induction of specific immune tolerance. Immunotherapeutical approaches could achieve complete cure of T1D or reverse unfavourable development of this serious disease (and prevent cardiovascular and metabolical complications of the patients). Project is focused on creation of laboratory procedure which would lead to clinical application of immunological preparation based on genetically modified tolerogenic T lymphocytes and dendritic cells. This therapeutical approach could be also original medical treatment for wider spectra of autoimmune disease such as multiple sclerosis and rheumatoid arthritis. (en)
Title
  • Novel treatment of genetically determined metabolic disease, type 1 diabetes, using an immunotherapeutical approach. (en)
  • Studium léčebných možností diabetes mellitus 1. typu jako geneticky determinované metabolické choroby s využitím nových imunoterapeutických postupů (cs)
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  • Type 1 diabetes; immunotherapy; autoimmunity; genetical determination; Foxp3. (en)
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