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  • The grant proposal is focused on the investigation of fluorinated phosphonates such as diethyl trifluoromethyl phosphonate, diethyl difluoromethyl phosphonate and tetraethyl fluoromethylenediphosphonate for the nucleophilic introduction of fluorinated groups. This methodology will allow access to compounds containing trifluoromethyl (-CF3), difluoromethyl (-CHF2), difluoromethylene (-CF2-) and fluoromethyl (-CH2F, -CHF-, -CF=) groups, important structural motives in the design of modern biologically active compounds and functional materials. (en)
  • Tento grantový návrh se zaměřuje na výzkum fluorovaných fosfonátů jako např. diethyl trifluoromethyl fosfonátu, diethyl difluoromethyl fosfonátu a tetraethyl fluoromethyléndifosfonátu pro nukleofilní zavedení fluorovaných funkčních skupin. Tato metodologie umožní přípravu látek obsahujících trifluoromethyl (-CF3), difluoromethyl (-CHF2), difluoromethylén (-CF2-) a fluoromethyl (-CH2F, -CHF-, -CF=) skupiny. Tyto sloučeniny jsou důležité při designu moderních biologicky aktivních látek a (cs)
Title
  • Nukleofilní zavedení fluorovaných funkčních skupin pomocí organofosforových sloučenin (cs)
  • Nucleophilic introduction of fluorinated groups using organo-phosphorus compounds (en)
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  • nucleophilic fluoroalkylation; fluorinated compounds; organo-phosphorus compounds (en)
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