About: Biosafe plant virus expression system for transient production of human papillomavirus oncoproteins and their use for therapeutic vaccine development     Goto   Sponge   NotDistinct   Permalink

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  • Cílem projektu je transientní exprese epitopů z onkoproteinů E6 a E7 lidského papillomaviru HPV16 v rostlinách pomocí dekonstruovaných virových vektorů a jejich využití k vývoji experimentálních vakcín pro terapii nádorů vyvolaných HPV16. (cs)
  •  The aim of the proposed project is to prepare protein immunogens derived from human papillomavirus HPV16 and optimization of their expression in plants for developing experimental therapeutic anti-HPV16 vaccines. We propose the production of different proteins containing immunodominant HPV16 epitopes from the E7 or E6 oncoproteins. We would like to develop the conditions leading to the high transient expression levels of heterologous proteins. The novelty of our attitude will be the new systems relied on a deconstructed TMV and PVX replicon strategy, which allows a stringent containtment of the recombinant viruses and provides us with biosafe transient expression units. The used host plants will be transgenic and non-transgenic N. benthamiana, a nonfood and nonfeed. We propose a strategy of economical expression of pharmaceutical proteins using viral vectors with high biosafety containment and without Agrobacterium contamination. Immunogenicity of the produced proteins will be examined in a mouse model by the detection of specific humoral, cell-mediated, and anti-tumor immunity. (en)
Title
  • Biosafe plant virus expression system for transient production of human papillomavirus oncoproteins and their use for therapeutic vaccine development (en)
  • Biologicky bezpečný expresní systém založený na rostlinných virech pro transientní expresi papillomavirových onkoproteinů a vývoj terapeutické vakcíny (cs)
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  • transientní exprese; rostlinný virový vektor; bezpečnost; papilloma virus; onkoprotein (en)
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