About: Characterization of the Fur phenotype of mutants of Pseudomonas aeruginosa: over-production of components of iron transport system.

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About: Characterization of the Fur phenotype of mutants of Pseudomonas aeruginosa: over-production of components of iron transport system. Goto Sponge NotDistinct Permalink

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rdf:type	http://linked.opendata.cz/ontology/domain/vavai/Projekt
Description	Projekt se zabývá charakterizací transportního mechanismu pro FeIII, jednoho z faktorů virulence, u Fur mutantů P. aeruginosa a možným využitím těchto poznatků v biotechnologiích. Projekt řeší následující cíle: 1. vztah mezi nadprodukcí pyoverdinu a jeho specifického receptoru u Fur mutantů, 2. maximální biosyntetickou kapacitu pro komponenty FeIII-transportního systému v rekombinantních kmenech a Fur mutantech a 3. charakterizaci změn ve Fur regulonu u rodičovského a Fur fenotypu. Metodami rekombinantní DNK budou připraveny rekombinantní kmeny obou fenotypů, u nichž bude sledována nadprodukce komponent FeIII-transportního systému za definovaných kultivačních podmínek v míchaném bioreaktoru. Pomocí metody DNA microarray budou studovány změny ve Fur regulonu u rodičovského a Fur fenotypu jako odpověď buněk na přítomnost vysoké koncentrace FeIII v mediu. Nadprodukované komponenty transportního systému lze využít v medicíně, farmacii a dalších oblastech vědy a výzkumu. (cs) Project deals with characterization of FeIII transport system, a factor of virulence, in Fur mutants of P. aeruginosa regarding application of knowledge in biotechnologies. Study is aimed at 1. relationship between overproduction of pyoverdin and its specific receptor in Fur mutants, 2. biosynthetic capacity for FeIII transport system components of recombinant strains and Fur mutants, and 3. regulatory changes in Fur regulon in wild-type and Fur phenotypes. The recombinant strains of both phenotypes will be prepared by means of techniques of recombinant DNA and overproduction of components of transport system will be studied in stirred bioreactor under defined growth conditions. Regulatory changes of the Fur regulon of wild-type and Fur phenotypes will be studied using technique of DNA microarray as a response to high concentration of iron in medium. Components of FeIII transport system can be exploited in medicine, pharmaceutical industry or other fields of science and industry. (en)
Title	Charakterizace Fur fenotypu mutantů Pseudomonas aeruginosa: nadprodukce komponent transportního systému pro FeIII. (cs) Characterization of the Fur phenotype of mutants of Pseudomonas aeruginosa: over-production of components of iron transport system. (en)
http://linked.open...vai/cislo-smlouvy	http://linked.opendata.cz/resource/domain/vavai/cep/smlouva/KJB500200703
http://linked.open...lsi-vedlejsi-obor	http://linked.opendata.cz/resource/domain/vavai/cep/obor/EI
http://linked.open...avai/druh-souteze	http://linked.opendata.cz/resource/domain/vavai/cep/druh-souteze/VS
http://linked.open...domain/vavai/faze	http://linked.opendata.cz/resource/domain/vavai/cep/faze/36955864
http://linked.open...vavai/hlavni-obor	http://linked.opendata.cz/resource/domain/vavai/cep/obor/EE
http://linked.open...vai/vedlejsi-obor	http://linked.opendata.cz/resource/domain/vavai/cep/obor/EB
http://linked.open...vavai/id-aktivity	http://linked.opendata.cz/resource/domain/vavai/cep/aktivita/KJ
http://linked.open.../vavai/id-souteze	http://linked.opendata.cz/resource/domain/vavai/cep/soutez/SAV02007-B
http://linked.open...n/vavai/kategorie	http://linked.opendata.cz/resource/domain/vavai/cep/kategorie/1
http://linked.open...vai/klicova-slova	Pseudomonas aeruginosa; iron transport; siderophore overproduction; Fur mutant; receptor; pyoverdin; recombinant strain; DNA microarray; fur gene; Fur regulon (en)
http://linked.open...avai/konec-reseni	2009-12-31 (xsd:date)
http://linked.open...nujicich-prijemcu	0 (xsd:integer)
http://linked.open...avai/poskytovatel	http://linked.opendata.cz/resource/domain/vavai/cep/poskytovatel/AV0
http://linked.open...avai/start-reseni	2007-01-01 (xsd:date)
http://linked.open...ai/statni-podpora	1258 (xsd:integer)
http://linked.open...vavai/typProjektu	http://linked.opendata.cz/resource/domain/vavai/cep/typ/P
http://linked.open...ai/uznane-naklady	1258 (xsd:integer)
http://linked.open...ai/pocet-prijemcu	1 (xsd:integer)
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http://linked.open...ai/pocet-vysledku	1 (xsd:integer)
http://linked.open...ku-zverejnovanych	1 (xsd:integer)
is http://linked.open...ain/vavai/projekt of	http://linked.opendata.cz/resource/domain/vavai/cep/ucast/2007/KJB500200703/ico-61388971 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/2008/KJB500200703/ico-61388971 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/2009/KJB500200703/ico-61388971 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/2010/KJB500200703/ico-61388971

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