About: Characterization of telomer chromatin proteins     Goto   Sponge   NotDistinct   Permalink

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  • The aim of the proposed project is a detailed analysis of nucleoprotein complexes of telomeres. The project is focused on characterization of previously detected 40 kDa telomere-binding protein, its purification and partial sequencing. Besides, characterization of telomeric chromatin, namely the acetylation state of its histones will be performed using immunochemical approaches. The outcomes of the project will provide knowledge on the role of telomer-binding proteins in telomerase regulation. The results obtained could be applied in biotechnology and medicine. (en)
  • Cílem projektu je bližší analýza nukleoproteinových komplexů telomer. Projekt je zaměřen na charakterizaci již detekovaného 40 kDa telomer-vazebného proteinu, který bude purifikován a částečně sekvenován. Kromě toho bude provedena charakterizace telomerového chromatinu, především studie acetylačního stavu jeho histonů pomocí imunochemických přístupů. Přínosem projektu bude bližší poznání úlohy telomer-vazebných proteinů v regulaci telomerázy. Získané poznatky by mohly nalézt uplatnění v biotechnol. a med. aplikacích. (cs)
Title
  • Characterization of telomer chromatin proteins (en)
  • Charakterizace proteinů telomerového chromatinu (cs)
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  • Plant telomere-binding proteins; purification; telomerace inhibition; chromatin; histone acetylation; DNA-protein interaction; (en)
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